{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:49:54Z","timestamp":1782100194125,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Results from observational studies have shown that obesity has a mild to moderate association with influenza\u2010like illness (ILI) severity and hospitalization risk. Using data from the ALIC\n                      <jats:sup>4<\/jats:sup>\n                      E Randomized Clinical Trial (RCT), this study investigated the relationship between obesity and ILI severity, time to recovery, and oseltamivir effectiveness in the obese population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 2622 adults (\u2265\u200918\u2009years old) from the ALIC\n                      <jats:sup>4<\/jats:sup>\n                      E RCT were categorized by body mass index (BMI) into under\/normal weight (BMI\u2009&lt;\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), overweight (BMI\u2009\u2265\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and &lt;\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), and obesity (BMI\u2009\u2265\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). ILI symptom severity, time to recovery, and oseltamivir effectiveness were assessed across these weight groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At presentation, ILI symptom severity was not different between weight groups. However, time to recovery was longer for obese patients compared to under\/normal weight patients, with adjusted HR 0.88 (95% CI 0.79\u20130.99). The mean time to recovery was 6.6\u2009days (95% CI 6.0\u20137.1) for obese patients, 6.2\u2009days (95% CI 5.8\u20136.6) for overweight, and 5.7\u2009days (95% CI 5.4\u20136.1) for under\/normal weight patients. Obese patients had similar benefits from oseltamivir treatment compared to under\/normal weight patients, with an average of 0.8\u2009days gained from oseltamivir (95% CI 0.7\u20131) and 0.5\u2009days (95% CI 0.4\u20130.7), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ILI symptom severity at presentation was equally distributed between the three weight groups. However, their time to recovery was approximately 1 day longer compared to under\/normal weight patients. The effectiveness of oseltamivir appears to be similar between the two groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70185","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T10:57:52Z","timestamp":1762772272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Obesity in Recovery From Influenza\u2010Like Illness and Effectiveness of Oseltamivir"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9434-292X","authenticated-orcid":false,"given":"Oanh\u00a0Ngoc","family":"Nguyen","sequence":"first","affiliation":[{"name":"CARA Network, School of Public Health, Physiotherapy and Sports Science University College Dublin  Dublin Ireland"},{"name":"National Centre for Pharmacoeconomics  Dublin Ireland"},{"name":"Old Stone Building, Trinity Centre for Health Sciences, St. James's Hospital  Dublin 8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6181-8154","authenticated-orcid":false,"given":"Nathaly","family":"Garz\u00f3n\u2010Orjuela","sequence":"additional","affiliation":[{"name":"CARA Network, School of Public Health, Physiotherapy and Sports Science University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9443-2837","authenticated-orcid":false,"given":"Alike\u00a0W.","family":"van der Velden","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-3453","authenticated-orcid":false,"given":"Christopher\u00a0C.","family":"Butler","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6583-4300","authenticated-orcid":false,"given":"Akke","family":"Vellinga","sequence":"additional","affiliation":[{"name":"CARA Network, School of Public Health, Physiotherapy and Sports Science University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"European Centre for Disease Prevention and Control.Factsheet About Seasonal Influenza. 18 January 2024 https:\/\/www.ecdc.europa.eu\/en\/seasonal\u2010influenza\/facts\/factsheet."},{"issue":"5","key":"e_1_2_11_3_1","first-page":"305","article-title":"The Causes and Diagnosis of Influenza\u2010Like Illness","volume":"33","author":"Kelly H.","year":"2004","journal-title":"Australian Family Physician"},{"key":"e_1_2_11_4_1","unstructured":"Health Protection Surveillance Centre.Influenza Surveillance Reports. 18 January 2024 https:\/\/www.hpsc.ie\/az\/respiratory\/influenza\/seasonalinfluenza\/surveillance\/influenzasurveillancereports\/."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-01035-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000301"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12156"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7174-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12618"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.131"},{"key":"e_1_2_11_11_1","unstructured":"Centers for Disease Control and Prevention.Influenza Antiviral Medications: Summary for Clinicians 2023. 18 January 2024 https:\/\/www.cdc.gov\/flu\/professionals\/antivirals\/summary\u2010clinicians.htm."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2021.311"},{"key":"e_1_2_11_13_1","first-page":"510","article-title":"Characteristics and Timing of Treatment Among Patients With Influenza\u2010Like Illness","volume":"28","author":"Garcia C. J.","year":"2019","journal-title":"Pharmacoepidemiology and Drug Safety"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2945"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu224"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32982-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02288-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00046-2018"},{"key":"e_1_2_11_19_1","unstructured":"World Health Organization.Obesity and Overweight.2024 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."},{"key":"e_1_2_11_20_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2023"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01071"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24946"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy700"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.03.008"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62449-1"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.70185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:22:50Z","timestamp":1782098570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.70185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/irv.70185"],"URL":"https:\/\/doi.org\/10.1111\/irv.70185","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.70185\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70185\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70185\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70185\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70185\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70185\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70185\/v2\/review1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70185"}}