{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:47:08Z","timestamp":1772160428024,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["68616285"],"award-info":[{"award-number":["68616285"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We evaluated whether having early COVID\u201019 reduced the severity of subsequent Omicron infection, assessing activities of daily living (ADL), healthcare utilization and illness duration. Comparisons were made between persons with (1) early COVID\u201019\u2010compatible illness with a negative test, (2) early lab\u2010confirmed SARS\u2010CoV\u20102 14\u201326\u2009months and (3) early lab\u2010confirmed SAR\u2010CoV\u20102 &gt;\u200926\u2009months before Omicron infection. Among 261 patients with laboratory\u2010confirmed Omicron, 177 (68%) had COVID\u201019 in 2020, a median of 793\u2009days (IQR, 659\u2013902) prior to Omicron infection. Compared to no early COVID\u201019, COVID\u201019 14\u201326\u2009months, but not &gt;\u200926\u2009months, before was associated with reduced impact on ADL during first Omicron infection (OR 0.52, 95% CI 0.29\u20130.93).<\/jats:p>","DOI":"10.1111\/irv.70197","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:39:27Z","timestamp":1768282767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early COVID\u201019 and Severity of Subsequent Omicron Infection in Ontario Canada"],"prefix":"10.1111","volume":"20","author":[{"given":"Caroline","family":"Kassee","sequence":"first","affiliation":[{"name":"Department of Microbiology Sinai Health  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altynay","family":"Shigayeva","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sinai Health  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Kandel","sequence":"additional","affiliation":[{"name":"Michael Garron Hospital, Toronto East Health Network  Toronto Canada"},{"name":"Department of Medicine University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna","family":"Farooqi","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sinai Health  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sinai Health  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Claude","family":"Gingras","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Sinai Health  Toronto Canada"},{"name":"Department of Molecular Genetics University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda\u00a0L.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sinai Health  Toronto Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sinai Health  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne\u00a0L.","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto  Toronto Canada"},{"name":"University Health Network  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Major","sequence":"additional","affiliation":[{"name":"Pfizer Canada  Kirkland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Mazzulli","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sinai Health  Toronto Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Mubareka","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Canada"},{"name":"Sunnybrook Health Sciences Centre  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas\u00a0Rao","family":"Valluri","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Martin","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moe\u00a0H.","family":"Kyaw","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u00a0M.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Pfizer Inc.  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"McGeer","sequence":"additional","affiliation":[{"name":"Department of Microbiology Sinai Health  Toronto Canada"},{"name":"Lunenfeld\u2010Tanenbaum Research Institute Sinai Health  Toronto Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.230721"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15071"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00271-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44973-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02465-5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20043335"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00801\u20105"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010024\u201010331\u20101"},{"key":"e_1_2_12_10_1","unstructured":"Statistics Canada \u201cPostal Code Conversion File Plus (PCCF+) \u201d Version 7C Reference Guide (2019)."},{"key":"e_1_2_12_11_1","unstructured":"Public Health Ontario \u201cWeekly Epidemiological Summary \u201d SARS\u2010CoV\u20102 Genomic Surveillance in Ontario June 2 2023 Toronto Ontario Canada (2023) accessed June 30 2024 https:\/\/www.publichealthontario.ca\/\u2010\/media\/documents\/ncov\/epi\/covid\u201019\u2010sars\u2010cov2\u2010whole\u2010genome\u2010sequencing\u2010epi\u2010summary.pdf."},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2292071"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856\u2010024\u201000539\u20102"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.70197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.70197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:12:31Z","timestamp":1769595151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.70197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/irv.70197"],"URL":"https:\/\/doi.org\/10.1111\/irv.70197","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.70197\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.70197\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70197"}}