{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:51:23Z","timestamp":1782514283518,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute otitis media (AOM) affects over 709 million individuals globally each year, more than half of whom are children &lt;\u20095\u2009years. Respiratory syncytial virus (RSV) is a leading viral cause of pediatric respiratory illness. We aimed to estimate the burden of RSV in children &lt;\u20095\u2009years with AOM<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review of studies reporting RSV identified through laboratory testing in children &lt;\u20095\u2009years with AOM. We searched eight databases from January 1, 1996, to May 9, 2025. We extracted data on RSV proportion in AOM and on co\u2010detection of bacterial pathogens. We reported pooled proportions using random\u2010effects meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 27 studies encompassing 8342 children with AOM. The pooled proportion of RSV in children with AOM was 16.9% (95% CI 11.0\u201323.8,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200994.9%). RSV proportion was higher in inpatient\u2010based studies, in studies conducted during peak RSV seasons, and in children aged &lt;\u200912\u2009months. Among RSV\u2010positive AOM cases, an estimated 67.4% (95% CI 15.4\u2013100) had at least one bacterial co\u2010detection. The most frequent bacteria co\u2010detected were\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      <\/jats:styled-content>\n                      , followed by\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Haemophilus influenzae<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Moraxella catarrhalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RSV is a common contributor to AOM in children &lt;\u20095\u2009years. Our findings indicate that RSV\u2010associated AOM often involves concurrent bacterial detection. These results highlight the potential impact of recently introduced passive RSV immunization, such as maternal immunization and long\u2010acting monoclonal antibody, in reducing AOM incidence and its complications. Preventing RSV in early childhood could lower the overall burden of AOM and decrease the need for antibiotics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70223","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:55:24Z","timestamp":1770278124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Burden of Respiratory Syncytial Virus in Children With Acute Otitis Media: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-080X","authenticated-orcid":false,"given":"Sebastien","family":"Kenmoe","sequence":"first","affiliation":[{"name":"Centre for Global Health, Usher Institute University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Dozier","sequence":"additional","affiliation":[{"name":"Library &amp; University 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