{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:29:27Z","timestamp":1788542967840,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI) in adults, especially older individuals, yet data on burden in Thailand are limited. This study aimed to describe clinical characteristics and mortality risk factors of RSV\u2010related hospitalizations in Thai adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis using Thailand's national hospital database, including adults aged \u2265\u200918\u2009years hospitalized with RSV\u2010associated ARIs between June 2016 and September 2024, identified using ICD\u201010 codes J12.1, J20.5, J21.0, and B97.4. Demographics, case fatality ratio, and healthcare resource utilization were assessed. Multivariable logistic regression identified predictors of in\u2010hospital mortality, and Kaplan\u2013Meier analysis estimated 60\u2010day overall survival by age and comorbidity status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1595 RSV\u2010related hospitalizations, the mean age was 66.5\u2009years; 72.0% were aged \u226560\u2009years and 78.4% had \u2265\u20091 comorbidity, most commonly hypertension, diabetes, chronic respiratory disease, and chronic heart disease. The median length of stay (LOS) was 7\u2009days, 17.3% required oxygen therapy, and 8.2% received invasive mechanical ventilation (IMV). The in\u2010hospital mortality was 9.53%. Mortality was independently associated with age \u2265\u200975\u2009years (mOR 1.83,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), LOS \u2265\u20097\u2009days (1.95,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), IMV (2.94,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), pneumonia (4.10, p\u2009&lt;\u20090.001), and acute myocardial infarction (3.05,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). The 60\u2010day survival rate was 88.2%, declining to 84.0% in patients aged \u2265\u200975\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 87.1% in those with comorbidities versus 92.2% in those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RSV causes substantial morbidity and mortality in Thai adults, especially those aged \u2265\u200975\u2009years and with chronic comorbidities, underscoring the need for strengthened RSV surveillance and prevention strategies.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Thai Clinical Trials Registry: TCTR20250929005\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70263","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:17:57Z","timestamp":1778242677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Respiratory Syncytial Virus Hospitalizations Among Adults in Thailand: A Nationwide Retrospective Observational Study (RSV\u2010HAT)"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6444-6542","authenticated-orcid":false,"given":"Kanrutai","family":"Jarottammarat","sequence":"first","affiliation":[{"name":"Department of Disease Control Ministry of Public Health  Nonthaburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8098-9288","authenticated-orcid":false,"given":"Kanokkarn","family":"Pinyopornpanish","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-5822","authenticated-orcid":false,"given":"Chadakan","family":"Yan","sequence":"additional","affiliation":[{"name":"Medical Affairs, Vaccines, GSK  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4311-1710","authenticated-orcid":false,"given":"Bussakorn","family":"Mahakkanukrauh","sequence":"additional","affiliation":[{"name":"Medical Affairs, Vaccines, GSK  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-8780","authenticated-orcid":false,"given":"Otavio","family":"Cintra","sequence":"additional","affiliation":[{"name":"Medical Affairs, Vaccines, International, GSK  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-2541","authenticated-orcid":false,"given":"Adriana","family":"Guzman\u2010Holst","sequence":"additional","affiliation":[{"name":"RWE &amp; HO Research, GSK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-6254","authenticated-orcid":false,"given":"Phichayut","family":"Phinyo","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Department of Biomedical Informatics and Clinical Epidemiology (BioCE), Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-6773","authenticated-orcid":false,"given":"Wipa","family":"Reechaipichitkul","sequence":"additional","affiliation":[{"name":"Division of 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Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz059"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043951"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010025\u201001220\u20104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010023\u201000777\u20102"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2024.05.015"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit471"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015098"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12855"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.70039"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2025.2523602"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.07.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12971"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12793"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9121990"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473\u20103099(18)30310\u20104"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021\u2010052089"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.Es.2021.26.29.2100706"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7029a1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6748"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/idr16040057"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab595"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209604"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213836"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307079"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20102600(25)00048\u20107"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)01738\u20100"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.15775"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa2514268"}],"container-title":["Influenza 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