{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:00:01Z","timestamp":1781830801620,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01IP001074"],"award-info":[{"award-number":["U01IP001074"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In India, no publicly funded seasonal influenza immunization is ongoing, partly because cost\u2010effectiveness is yet to be established. We estimate the cost\u2010effectiveness and budgetary impact of introducing seasonal influenza vaccination among adults aged \u2265\u200960\u2009years in India, a known high\u2010risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Estimates of disease burden including disability adjusted life years (DALYs) were generated from 3\u2010year community cohorts and hospital\u2010based study set up at four sites to estimate incidence of symptomatic acute respiratory infections (ARI), health care utilization, costs and outcomes and applied to India's 2021 estimated population. We used a decision analysis model from an abridged societal perspective for implementation of an inactivated trivalent influenza vaccination programme for older adults (aged \u2265\u200960\u2009years) using either facility\u2010based or outreach\u2010based approaches. We estimated incremental cost\u2010effectiveness ratio (ICER) per DALY averted and used India's per capita gross domestic product of US$ 2238 for 2021 as the cost\u2010effectiveness threshold. We performed deterministic and probabilistic sensitivity analyses. We also estimated ICER for immunizing all those above 65\u2009years or with comorbidities. Using financial cost of the vaccination programme and the direct medical cost of disease averted we estimated its budgetary impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, older adults in India had 5.3 (95% CI: 3.6\u20137.7) million influenza\u2010ARIs resulting in 36,149 (95% CI: 30,076\u201343,268) hospitalizations and 84,613 (95% CI: 39,895\u2013155,454) deaths. It amounted to a total of 974,019 DALYs and US$ 66.6 million. As compared with no vaccination, facility\u2010based and outreach\u2010based influenza vaccination had an ICER of US$1979 and US$1851, respectively, below the cost\u2010effectiveness threshold. In all sensitivity and scenario analyses, ICER estimates were below the threshold and vaccinating those above 60\u2009years with specified comorbidities using a passive approach was found to be most cost\u2010effective with least budgetary impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Annually vaccinating older adults against influenza was found to be cost\u2010effective in the majority of scenarios considered in the study. Given the budgetary implication, it might be prudent to focus on those with co\u2010morbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70264","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:00:25Z","timestamp":1777600825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Burden of Influenza and Cost\u2010Effectiveness Analysis of Introduction of an Influenza Vaccination Programme Among Older Adults in India"],"prefix":"10.1111","volume":"20","author":[{"given":"Anand","family":"Krishnan","sequence":"first","affiliation":[{"name":"Centre for Community Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-0876","authenticated-orcid":false,"given":"Aslesh 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