{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:00:43Z","timestamp":1790650843393,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The COVID\u201019 pandemic profoundly altered the circulation of respiratory viruses in children, changing the epidemiology of acute lower respiratory tract infections. In the postpandemic period, respiratory pathogens showed marked temporal variability. The 2024\u20132025 season was the first respiratory syncytial virus (RSV) season in Italy during which RSV immunoprophylaxis with nirsevimab was implemented, allowing evaluation of recent trends in pediatric hospitalizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective multicenter study across 16 pediatric hospitals in Italy. Hospitalizations of children younger than 18\u2009years with RSV, influenza, adenovirus, parainfluenza virus, rhinovirus infection, or bronchiolitis of unspecified viral etiology were identified from January 2019 to March 2025 using ICD\u20109\u2010CM diagnostic codes. Annual and monthly hospitalization rates per 100,000 children were calculated using national demographic data. Temporal trends were assessed across six consecutive seasons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 23,981 hospitalizations were recorded. RSV was the most frequent pathogen (42.5%), followed by influenza (18.6%), adenovirus (9.9%), and rhinovirus (7.3%). Hospitalizations declined sharply in 2020 and subsequently increased, peaking in 2024 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094903; +30.8% vs. 2022). During the 2024\u20132025 season, total admissions decreased by 17.2% compared with 2023\u20132024 (3390 vs. 4095), mainly due to a marked reduction in RSV\u2010related hospitalizations (\u221241.6%, 1230 vs. 2107), with modest increases in influenza\u2010, adenovirus\u2010, and rhinovirus\u2010associated admissions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nationwide analysis describes postpandemic trends in pediatric respiratory virus hospitalizations in Italy, highlighting changing pathogen\u2010specific patterns and the need for continued viral surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.70296","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:50:38Z","timestamp":1790650238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postpandemic Trends in Pediatric Respiratory Virus Hospitalizations: A Multicenter Study, 2019\u20132025"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7463-8567","authenticated-orcid":false,"given":"Federica","family":"Attaianese","sequence":"first","affiliation":[{"name":"Meyer Children's Hospital IRCCS Pediatric Unit  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Campani","sequence":"additional","affiliation":[{"name":"Meyer Children's Hospital IRCCS Pediatric Unit  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1105-1500","authenticated-orcid":false,"given":"Sandra","family":"Trapani","sequence":"additional","affiliation":[{"name":"Meyer Children's Hospital IRCCS Pediatric Unit  Florence Italy"},{"name":"Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Alberti","sequence":"additional","affiliation":[{"name":"IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-6671","authenticated-orcid":false,"given":"Maurizio","family":"Aric\u00f2","sequence":"additional","affiliation":[{"name":"Pediatric Unit S. Spirito Hospital, Azienda Sanitaria Locale di Pescara  Pescara Italy"},{"name":"Interdisciplinary Department of Medicine Aldo Moro University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Attanasi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bertolucci","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Pneumonology and Allergology Section Pisa University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bressan","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department University of Padova  Padova Italy"},{"name":"Department of Woman's and Child's Health University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9e","family":"Caselli","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Unit AOUC Policlinico di Bari, Children Hospital Giovanni XXIII  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Casotto","sequence":"additional","affiliation":[{"name":"Department of Woman's and Child's Health University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cazzato","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Mother and Child Health Salesi Children's Hospital  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Felici","sequence":"additional","affiliation":[{"name":"Pediatric and Pediatric Emergency Unit, Children's Hospital AO SS Antonio e Biagio e C. 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