{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:50:01Z","timestamp":1791967801653,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003921","name":"Department of Health and Aged Care, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The emergence of viruses with reduced susceptibility to antivirals poses an ongoing risk which could limit their effectiveness. Here we report a cluster of A(H3N2) viruses detected in Tasmania, Australia, with a PA gene mutation A37T that showed mild reductions in susceptibility in\u00a0vitro to baloxavir (3.47\u2010 to 16.33\u2010fold increased EC\n                    <jats:sub>50<\/jats:sub>\n                    ) when compared to wild\u2010type influenza A(H3N2) viruses. When the PA\u2010A37T and PA\u2010I38T substitutions were combined and tested in IRINA assay, eightfold higher inhibition was seen compared to PA\u2010I38T alone. On\u2010going monitoring of influenza viruses for reduced susceptibility to antivirals remains an important part of seasonal and zoonotic influenza surveillance.\n                  <\/jats:p>","DOI":"10.1111\/irv.70312","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:07:17Z","timestamp":1790215637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Cluster of Influenza A(H3N2) Viruses in 2024 From Tasmania, Australia, With Reduced Susceptibility to Baloxavir"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0545-244X","authenticated-orcid":false,"given":"Saira","family":"Hussain","sequence":"first","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"},{"name":"Department of Microbiology and Immunology University of Melbourne, at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8840-9104","authenticated-orcid":false,"given":"Charmaine","family":"Chia","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute Agency for Science, Technology and Research (A*STAR)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-2529","authenticated-orcid":false,"given":"Ashwin","family":"Muraleetharan","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Mo","family":"Deng","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-9442","authenticated-orcid":false,"given":"Xiaomin","family":"Dong","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Presa","family":"Chanthalavanh","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-4699","authenticated-orcid":false,"given":"Emi","family":"Takashita","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Influenza Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7616-4680","authenticated-orcid":false,"given":"Clyde","family":"Dapat","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1806-1894","authenticated-orcid":false,"given":"Jessica E.","family":"Miller","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-2839","authenticated-orcid":false,"given":"Heidi","family":"Peck","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5634-9154","authenticated-orcid":false,"given":"Raphael T. C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute Agency for Science, Technology and Research (A*STAR)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Williamson","sequence":"additional","affiliation":[{"name":"Pathology Department Royal Hobart Hospital  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Cooley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases Royal Hobart Hospital  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-9640","authenticated-orcid":false,"given":"Sebastian","family":"Maurer\u2010Stroh","sequence":"additional","affiliation":[{"name":"Bioinformatics Institute Agency for Science, Technology and Research (A*STAR)  Singapore"},{"name":"Infectious Diseases Labs Agency for Science Technology and Research (A*STAR)  Singapore"},{"name":"Yong Loo Lin School of Medicine and Department of Biological Sciences National University of Singapore (NUS)  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-418X","authenticated-orcid":false,"given":"Ian G.","family":"Barr","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"},{"name":"Department of Microbiology and Immunology University of Melbourne, at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105499"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27890-4"},{"key":"e_1_2_9_4_1","first-page":"346","article-title":"Treatment\u2010Emergent Influenza Variant Viruses With Reduced Baloxavir Susceptibility: Impact on Clinical and Virologic Outcomes in Uncomplicated Influenza","volume":"221","author":"Uehara T.","year":"2020","journal-title":"Journal of Infectious Diseases"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105281"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2025.106217"},{"key":"e_1_2_9_7_1","first-page":"1735","article-title":"Detection of Variants With Reduced Baloxavir Marboxil and Oseltamivir Susceptibility in Children With Influenza a During the 2019\u20102020 Influenza Season","volume":"224","author":"Sato M.","year":"2021","journal-title":"Journal of Infectious Diseases"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105457"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03026"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2012.12.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2023.10.017"},{"key":"e_1_2_9_12_1","article-title":"Baloxavir Susceptibility of Seasonal Influenza Viruses During the First Seven Seasons of Clinical Use in Japan, 2017\/18 to 2023\/24","volume":"31","author":"Takashita E.","year":"2026","journal-title":"Euro Surveillance"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30004-9"}],"container-title":["Influenza and Other Respiratory 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