{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:44:21Z","timestamp":1775947461232,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T00:00:00Z","timestamp":1355270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic leg ulcers in patients with rheumatological diseases can cause significant morbidity. We performed a retrospective case review to describe the epidemiology, clinical features and outcome of chronic leg ulcers in this group of patients. Twenty\u2010nine patients with underlying rheumatological conditions, such as, rheumatoid arthritis (15 patients), systemic lupus erythematosus (8 patients), overlap syndromes (3 patients), systemic sclerosis (1 patient) and ankylosing spondylitis (1 patient) were included. The ulcers were mostly located around the ankle (55\u00b72%) and calves (37\u00b79%). The predominant aetiology of the ulcers, in decreasing order of frequency, was venous disease, multifactorial, vasculitis or vasculopathy, infective, pyoderma gangrenosum, ischaemic microangiopathy and iatrogenic. Treatment modalities included aggressive wound bed preparation, compression therapy (17 patients), changes in immunosuppressive therapy (15 patients), hyperbaric oxygen therapy (4 patients) and cellular skin grafting (2 patients). Management of chronic leg ulcers in rheumatological patients is challenging and the importance of careful clinicopathological correlation and treatment of the underlying cause cannot be overemphasised.<\/jats:p>","DOI":"10.1111\/iwj.12012","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T21:03:10Z","timestamp":1355432590000},"page":"601-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Chronic leg ulcers in adult patients with rheumatological diseases \u2013 a 7\u2010year retrospective review"],"prefix":"10.1111","volume":"11","author":[{"given":"Hui Y","family":"Chia","sequence":"first","affiliation":[{"name":"Dermatology, National Skin Centre  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark BY","family":"Tang","sequence":"additional","affiliation":[{"name":"Dermatology, National Skin Centre  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"507","article-title":"The frequency of leg ulceration in rheumatoid arthritis: a survey","volume":"10","author":"Thurtle OA","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1964.01600040005001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.106942"},{"key":"e_1_2_6_5_1","first-page":"534","article-title":"Lower extremity ulcers in connective tissue disease","volume":"10","author":"Shanmugam VK","year":"2008","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000284583"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1990.tb126267.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.7.816"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(87)80006-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8810"},{"key":"e_1_2_6_11_1","first-page":"CD001103","article-title":"Dressings for healing venous leg ulcers","author":"Palfreyman SJ","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_1","first-page":"CD000265","article-title":"Compression for venous leg ulcers","author":"O'Meara S","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_13_1","first-page":"CD004123","article-title":"Hyperbaric oxygen therapy for chronic wounds","volume":"4","author":"Kranke P","year":"2012","journal-title":"Cochrane Database Syst Rev"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:06:14Z","timestamp":1696244774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,12]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/iwj.12012"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12012","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,12]]},"assertion":[{"value":"2012-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}