{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:31:57Z","timestamp":1792204317745,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T00:00:00Z","timestamp":1361232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic venous ulceration (<jats:styled-content style=\"fixed-case\">CVU<\/jats:styled-content>) is the major cause of chronic wounds of lower extremities, and is a part of the complex of chronic venous disease. Previous studies have hypothesised that several thrombophilic factors, such as hyperhomocysteinaemia (<jats:styled-content style=\"fixed-case\">HHcy<\/jats:styled-content>), may be associated with chronic venous ulcers. In this study, we evaluated the prevalence of <jats:styled-content style=\"fixed-case\">HHcy<\/jats:styled-content> in patients with venous leg ulcers and the effect of folic acid therapy on wound healing.<\/jats:p><jats:p>Eighty\u2010seven patients with venous leg ulcers were enrolled in this study to calculate the prevalence of <jats:styled-content style=\"fixed-case\">HHcy<\/jats:styled-content> in this population. All patients underwent basic treatment for venous ulcer (compression therapy \u00b1 surgical procedures).<\/jats:p><jats:p>Patients with <jats:styled-content style=\"fixed-case\">HHcy<\/jats:styled-content> (group A) received basic treatment and administered folic acid (1\u00b72 mg\/day for 12 months) and patients without <jats:styled-content style=\"fixed-case\">HHcy<\/jats:styled-content> (group B) received only basic treatment. Healing was assessed by means of computerised planimetry analysis.<\/jats:p><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">HHcy<\/jats:styled-content> among patients with chronic venous ulcer enrolled in this study was 62\u00b706%. Healing rate was significantly higher (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) in group A patients (78\u00b775%) compared with group B patients (63\u00b733%).<\/jats:p><jats:p>This study suggests a close association, statistically significant, between <jats:styled-content style=\"fixed-case\">HHcy<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CVU<\/jats:styled-content>. Homocysteine\u2010lowering therapy with folic acid seems to expedite wound healing. Despite these aspects, the exact molecular mechanisms between homocysteine and <jats:styled-content style=\"fixed-case\">CVU<\/jats:styled-content> have not been clearly defined and further studies are needed.<\/jats:p>","DOI":"10.1111\/iwj.12042","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T16:26:48Z","timestamp":1361291208000},"page":"22-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Hyperhomocysteinaemia and chronic venous ulcers"],"prefix":"10.1111","volume":"12","author":[{"given":"Stefano","family":"de Franciscis","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Science, School of Medicine University Magna Graecia of Catanzaro  Catanzaro Italy"},{"name":"Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Graecia of Catanzaro  Catanzaro 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Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico M","family":"Stillitano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Science, School of Medicine University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[{"name":"Department of Health Science, School of Medicine University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Science, School of Medicine University Magna Graecia of Catanzaro  Catanzaro Italy"},{"name":"Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Graecia of Catanzaro  Catanzaro 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