{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:35:49Z","timestamp":1790847349847,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T00:00:00Z","timestamp":1361664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Transmetatarsal amputation (\n                    <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>\n                    ) represents an effective surgical procedure used to treat several clinical conditions such as forefoot infection, gangrene and chronic ulceration in diabetic patients.\n                    <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>\n                    permits walking without the need for prosthesis, but nevertheless is burdened with a high complications rate. The aim of this study was to evaluate the possibility to use platelet gel (\n                    <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>\n                    ) as an adjuvant therapy when performing\n                    <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>\n                    procedure in diabetic patients. In a 6\u2010year period, 26 diabetic patients had undergone\n                    <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>\n                    procedure followed by autologous PG applications (group A) and 32 patients had undergone\n                    <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>\n                    as sole procedure (group B). After\n                    <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>\n                    procedure, the treatment is based on outpatient management and consists of a weekly platelet\u2010rich plasma gel application on the surgical wound for 1\u2009month in group A and on clinical evaluation only for group B. For group A, healing rate was of 96\u00b715% and one patient (3\u00b784%) presented wound dehiscence, and no postoperative wound infections occurred. For group B, healing rate was of 59\u00b737%; severe infection of the stump prompted to the proximal amputations in 40\u00b762% of patients during the follow\u2010up period. PG application may be an effective adjuvant treatment to improve wound healing in diabetic dysvascular patients.\n                  <\/jats:p>","DOI":"10.1111\/iwj.12052","type":"journal-article","created":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T23:49:28Z","timestamp":1361749768000},"page":"612-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Application of platelet\u2010rich gel to enhance healing of transmetatarsal amputations in diabetic dysvascular patients"],"prefix":"10.1111","volume":"10","author":[{"given":"Raffaele","family":"Serra","sequence":"first","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Buffone","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dominijanni","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service Pugliese\u2010Ciaccio Hospital  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Molinari","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Montemurro","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"de Franciscis","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro 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