{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T21:00:43Z","timestamp":1778014843602,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>To compare the changes in microvascular blood flow in the small intestinal wall, wound contraction and fluid evacuation, using the established V.A.C. abdominal dressing (VAC<\/jats:styled-content> dressing) and a new abdominal dressing, the ABThera<\/jats:styled-content> open abdomen negative pressure therapy system (ABThera<\/jats:styled-content> dressing), in negative pressure wound therapy (NPWT<\/jats:styled-content>). Midline incisions were made in 12 pigs, which were subjected to treatment with NPWT<\/jats:styled-content> using the VAC<\/jats:styled-content> or ABThera<\/jats:styled-content> dressing. The microvascular blood flow in the intestinal wall, were measured before and after the application at topical negative pressures of \u221250, \u221275 and \u2212125 mmHg, using laser Doppler velocimetry. Wound contraction and fluid evacuation were also measured. Baseline blood flow was defined as 100% in all settings. The blood flow was significantly reduced, to 64\u00b76 \u00b1 6\u00b77% (P<\/jats:italic> < 0\u00b705) after the application of \u221250 mmHg using the VAC<\/jats:styled-content> dressing, and to 65\u00b73 \u00b1 9\u00b76% (P<\/jats:italic> < 0\u00b705) after the application of \u221250 mmHg with the ABThera<\/jats:styled-content> dressing. The blood flow was significantly reduced, to 39\u00b76 \u00b1 6\u00b77% (P<\/jats:italic> < 0\u00b705) after the application of \u2212125 mmHg using VAC<\/jats:styled-content>, and to 40\u00b75 \u00b1 6\u00b72% (P<\/jats:italic> < 0\u00b705) after the application of \u2212125 mmHg with ABThera<\/jats:styled-content>. No significant difference in the reduction in blood flow could be observed between the two groups. The ABThera<\/jats:styled-content> system gave significantly better fluid evacuation from the wound compared to the VAC<\/jats:styled-content> system. There was no difference between the dressings regarding the reduction in blood flow, but the ABThera<\/jats:styled-content> dressing afforded better drainage of the abdomen and better wound contraction than the VAC<\/jats:styled-content> dressing.<\/jats:p>","DOI":"10.1111\/iwj.12056","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T08:27:41Z","timestamp":1363854461000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparative study of the microvascular blood flow in the intestinal wall, wound contraction and fluid evacuation during negative pressure wound therapy in laparostomy using the V.A.C. abdominal dressing and the ABThera<\/scp> open abdomen negative pressure therapy system"],"prefix":"10.1111","volume":"12","author":[{"given":"Sandra","family":"Lindstedt","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Lund University 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