{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:09:59Z","timestamp":1784300999032,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:00:00Z","timestamp":1363132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Wound healing is an active and dynamic process that begins from the moment of injury. Any delay in the initiation of the response to injury can prolong the healing process. The aim of this study was to investigate the effects of topically applied fusidic acid and rifamycin on wound healing in a full\u2010thickness wound model. Ten female Sprague\u2010Dawley rats, aged 4 months and weighing 200\u2013250 g, were used. Four rifamycin (R), four fusidic acid (F) and four control (K) areas were generated on their backs by using a 5\u2010mm punch biopsy pen. On the 4th, 7th, 14th and 21st days, biopsies were taken from each wound area of all the rats. Fusidic acid group demonstrated a statistically significant increase of collagen and intensity of fibroblast proliferation on the 21st day of wound healing, whereas in the rifamycin group, healing time was, as expected, similar to physiological wound\u2010healing phases. Despite the limited number of subjects, topical fusidic acid was found to delay wound healing by prolonging fibroblast proliferation.<\/jats:p>","DOI":"10.1111\/iwj.12060","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T08:01:28Z","timestamp":1363248088000},"page":"106-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of the effects of topical fusidic acid and rifamycin on wound healing in rats"],"prefix":"10.1111","volume":"12","author":[{"given":"Mehmet S","family":"Gurel","sequence":"first","affiliation":[{"name":"Dermatology Department Istanbul Educational and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sillan","family":"Nayc\u0131","sequence":"additional","affiliation":[{"name":"Dermatology Department Istanbul Leprosy Dermatology and Venereology Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131 V","family":"Turgut","sequence":"additional","affiliation":[{"name":"Dermatology Department Istanbul Educational and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol R","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Pathology Department Istanbul Educational and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.038"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2004.09.004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(03)00046-4"},{"key":"e_1_2_5_6_1","first-page":"1361","article-title":"The effect of rifamycin SV on the wound\u2010healing process","volume":"26","author":"Benfer J","year":"1976","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1684\/ejd.2010.0833","article-title":"Fusidic acid in dermatology: an updated review","volume":"20","author":"Schofer H","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007997709110182"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.12.005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.244-269.2001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2001.01631.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00180.x"},{"key":"e_1_2_5_13_1","first-page":"113","article-title":"Topikal olarak uygulanan Nitrofurazon ve Rifamycinin tam kal\u0131nl\u0131kta yara iyile\u015fmesi \u00fczerine etkileri","volume":"27","author":"Saydam \u0130M","year":"2005","journal-title":"C. \u00dc. 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