{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:04:52Z","timestamp":1781723092954,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Venous ulcers are common, especially in the elderly, accounting for more than 50% of all lower extremity ulcers with important socioeconomic problems. Improving extracellular matrix functioning, by heparin administration, seems to be a way to support wound healing. A total of 284 patients with venous ulcers were recruited in a 4\u2010year period. All patients were subjected to the most appropriate treatment after considering their preference (compression therapy followed or not by vein surgery). Patients were randomised into two groups of 142 persons in each (group A and group B as cases and controls, respectively). Patients of group A, in addition to the basic treatment as described earlier, received administration of nadroparin 2850\u2009IU\/0.3\u2009ml through subcutaneous injection once a day for 12\u2009months, whereas group B patients received basic treatment alone. Healing was assessed by means of direct ulcer tracing with computerised planimetry. Group A showed a healing rate of 83\u00b780% at 12\u2009months, whereas that of group B was 60\u00b756%. Results by age group surprisingly showed that the group of older patients took the most advantage from long\u2010term treatment with low molecular weight heparin; this group also had lowest recurrence rate.<\/jats:p>","DOI":"10.1111\/iwj.12071","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T08:27:57Z","timestamp":1363854477000},"page":"150-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Low molecular weight heparin improves healing of chronic venous ulcers especially in the elderly"],"prefix":"10.1111","volume":"12","author":[{"given":"Raffaele","family":"Serra","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Science University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"},{"name":"Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Buffone","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Science University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Molinari","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Science University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Montemurro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Science University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Perri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Science University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico M","family":"Stillitano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Science University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Amato","sequence":"additional","affiliation":[{"name":"Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"},{"name":"Department of General, Geriatric, Oncologic Surgery and Advanced Technologies University \u201cFederico II\u201d of Naples Via Pansini Naples 5\u201080131 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"de Franciscis","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Science University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"},{"name":"Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Gracia of Catanzaro Viale Europa, Localit\u00e0 Germaneto Catanzaro 88100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6485.1855"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121739"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2005.10.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.11.036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.05.069"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30218-3"},{"key":"e_1_2_7_8_1","first-page":"224","article-title":"Effects of heparin on wound healing","volume":"23","author":"Galvan L","year":"1996","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-10-S1-A64"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr12035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.04.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.09.027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.06.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1683"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12042"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12071","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:47:55Z","timestamp":1696240075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,21]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/iwj.12071"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12071","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,21]]},"assertion":[{"value":"2013-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}