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An <jats:styled-content style=\"fixed-case\">IRB<\/jats:styled-content>\u2010approved, prospective, randomised, single\u2010centre clinical trial was performed. Included were patients with a diabetic foot ulcer of at least 4\u2010week duration without infection having adequate arterial perfusion. Patients were randomised to receive standard care alone or standard care with the addition of <jats:styled-content style=\"fixed-case\">EpiFix<\/jats:styled-content>. Wound size reduction and rates of complete healing after 4 and 6\u2009weeks were evaluated. In the standard care group (<jats:italic>n<\/jats:italic>\u2009=\u200912) and the <jats:styled-content style=\"fixed-case\">EpiFix<\/jats:styled-content> group (<jats:italic>n<\/jats:italic>\u2009=\u200913) wounds reduced in size by a mean of 32\u00b70%\u2009\u00b1\u200947\u00b73% versus 97\u00b71%\u2009\u00b1\u20097\u00b70% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090\u00b7001) after 4\u2009weeks, whereas at 6\u2009weeks wounds were reduced by \u22121\u00b78%\u2009\u00b1\u200970\u00b73% versus 98\u00b74%\u2009\u00b1\u20095\u00b78% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090\u00b7001), standard care versus <jats:styled-content style=\"fixed-case\">EpiFix<\/jats:styled-content>, respectively. After 4 and 6\u2009weeks of treatment the overall healing rate with application of <jats:styled-content style=\"fixed-case\">EpiFix<\/jats:styled-content> was shown to be 77% and 92%, respectively, whereas standard care healed 0% and 8% of the wounds (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090\u00b7001), respectively. Patients treated with <jats:styled-content style=\"fixed-case\">EpiFix<\/jats:styled-content> achieved superior healing rates over standard treatment alone. These results show that using <jats:styled-content style=\"fixed-case\">EpiFix<\/jats:styled-content> in addition to standard care is efficacious for wound healing.<\/jats:p>","DOI":"10.1111\/iwj.12097","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T08:57:20Z","timestamp":1370595440000},"page":"502-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":238,"title":["A prospective randomised comparative parallel study of amniotic membrane wound graft in the management of diabetic foot ulcers"],"prefix":"10.1111","volume":"10","author":[{"given":"Charles M","family":"Zelen","sequence":"first","affiliation":[{"name":"Department of Clinical Research Professional Education and Research Institute, Inc.  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