{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T21:08:43Z","timestamp":1784063323898,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T00:00:00Z","timestamp":1372118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to evaluate the benefit of vacuum\u2010assisted closure (VAC) therapy in the management of deep, alloplastic graft infections (Szilagyi grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) in the groin. From 2000 to 2009, we identified and included in our study 72 deep inguinal infections in 68 patients, involving native as well as synthetic graft or patch material. There were 29 early graft infections (&lt;30 days after implantation) and 43 late infections (\u226530 days after implantation). Among these, 17 cases involved native grafts\/patches (12 grafts and 5 patches), while 55 cases involved non\u2010native grafts\/patches [26 polytetrafluorethylene (<jats:styled-content style=\"fixed-case\">PTFE<\/jats:styled-content>) grafts and 24 Dacron grafts (Haemashield, Meadox Medical, Boston Scientific Corporation, Natick, NY; Gelsoft graft, Vascutek, Inchinnan, Renfrewshire, Scotland, UK; Intervascular, Mahwah, NJ); INVISTA, and 5 Vascu\u2010Guard<jats:sup>\u2122<\/jats:sup> bovine pericardial patches; Synovis Surgical Innovation]. All patients were treated with multiple wound debridements, graft salvage, sartorius myoplasty, intravenous antibiotics and VAC therapy until thorough surface healing was achieved. Exclusion criteria were an alloplastic graft infection with proximal expansion above the inguinal ligament, blood culture positive for septicaemia or septic anastomotic herald or overt bleeding. Nine months after initiation of therapy, overall, graft\/patch salvage was achieved in 61 of 72 (84\u00b77%) cases. Of the native graft\/patch group, infected graft material was replaced with an autogenous great saphenous vein graft or patch in four patients (23\u00b75%). In the non\u2010native group, vein or synthetic graft preservation without revision was achieved in 48 of 55 (87\u00b73%) patients. The mean duration of VAC therapy was 16 \u00b1 7\u00b77 days, and postoperative mean hospital stay was 25\u00b73 \u00b1 8\u00b75 days. In 23 of 72 (31\u00b79%) cases, a secondary closure of the wound was achieved; in the other 49 cases, wound healing was achieved by meshed split\u2010thickness skin grafting. Mean wound healing time for all wounds was 24\u00b73 \u00b1 12\u00b75 days. Specific complications during VAC therapy were wound fluid retention in 2 cases and an increased need for analgesics in 12 cases (16\u00b766%). Negative pressure wound therapy (<jats:styled-content style=\"fixed-case\">NPWT<\/jats:styled-content>) has been reported to be useful in the treatment of severe wound infections. Even in the presence of synthetic vascular graft material, <jats:styled-content style=\"fixed-case\">NPWT<\/jats:styled-content> can greatly simplify challenging wound\u2010healing problems leading to wound dehiscence and its sequelae. Our long\u2010term experience demonstrates the safety and effectiveness of VAC therapy in the management of deep graft infections.<\/jats:p>","DOI":"10.1111\/iwj.12110","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T06:50:39Z","timestamp":1372143039000},"page":"317-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Vacuum\u2010assisted closure therapy for vascular graft infection (Szilagyi grade <scp>III<\/scp>) in the groin\u2014a 10\u2010year multi\u2010center experience"],"prefix":"10.1111","volume":"12","author":[{"given":"Himanshu","family":"Verma","sequence":"first","affiliation":[{"name":"Narayana Institute of Vascular Sciences Narayana Hrudayalaya  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiriakos","family":"Ktenidis","sequence":"additional","affiliation":[{"name":"Ist Surgical University Clinic, Department of Vascular Surgery, Papageorgiou General Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbie K","family":"George","sequence":"additional","affiliation":[{"name":"Narayana Institute of Vascular Sciences Narayana Hrudayalaya  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Narayana Institute of Vascular Sciences Narayana Hrudayalaya  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90344-W"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199406000-00011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199404001-00015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2310\/6670.2008.00041"},{"key":"e_1_2_6_6_1","first-page":"81","article-title":"Vascular graft infection: an analysis of sixty\u2010two graft infections in 2411 consecutively implanted synthetic vascular grafts","volume":"98","author":"Lorentzen JE","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1980.01380110111017"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/jcm.28.4.664-669.1990","article-title":"Sequential analysis of staphylococcal colonization of body surfaces of patients undergoing vascular surgery","volume":"28","author":"Levy MF","year":"1990","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1890"},{"key":"e_1_2_6_10_1","first-page":"757","article-title":"Topical negative pressure therapy. 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