{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:41:05Z","timestamp":1792672865014,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:00:00Z","timestamp":1373328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) can be a debilitating chronic disease. The underlying cause of the disease is still not clear. <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> may be managed through numerous different medical or surgical procedures. Surgical treatment may consist of local excisions and reconstruction using a variety of methods: perforator flaps, skin grafts, local flaps, primary closure or secondary wound healing with vacuum and other devices. This report describes our experience with surgical excision and closure using platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) gel and Hyalomatrix <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>) in a patient with severe <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> involving most of the body surface. We treated the patient with resection of severe <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> of the nuchae and closure with <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> gel prepared with the <jats:styled-content style=\"fixed-case\">RegenKit<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> to promote neovascularisation and <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>, a delivery system for hyaluronic acid, to induce a neodermis at the wound bed and to stimulate regeneration in a humid and protected environment. Complete wound healing was achieved after 2 months. The obtained result proved the efficacy of this treatment without complications. No recurrence was observed during the 1 year after the surgical procedure. Severe <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> can be safely and effectively managed with wide excision, <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> gel and Hyalomatrix to achieve a successful outcome.<\/jats:p>","DOI":"10.1111\/iwj.12117","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T08:16:02Z","timestamp":1373357762000},"page":"338-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Severe hidradenitis suppurativa treatment using platelet\u2010rich plasma gel and Hyalomatrix"],"prefix":"10.1111","volume":"12","author":[{"given":"Fabio","family":"Nicoli","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery \u2018Policlinico Casilino\u2019 University of Tor Vergata in Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Balzani","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery \u2018Policlinico Casilino\u2019 University of Tor Vergata in Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Unit Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery \u2018Policlinico Casilino\u2019 University of Tor Vergata in Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram M","family":"Chilgar","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Maharashtra University of Health Sciences  Nashik India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Di Pasquali","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery \u2018Policlinico Casilino\u2019 University of Tor Vergata in Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Department of Immunology \u2018La Sapienza\u2019 University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bocchini","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery \u2018Policlinico Casilino\u2019 University of Tor Vergata in Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Agovino","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery \u2018Policlinico Casilino\u2019 University of Tor Vergata in Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Cervelli","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery \u2018Policlinico Casilino\u2019 University of Tor Vergata in Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00712_1.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.025"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283428d07"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.02.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07155.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70272-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2007.00019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08735.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0747"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2002.3899"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.09.063"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3181f77bd6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.75"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.2985"},{"key":"e_1_2_7_17_1","first-page":"623","volume-title":"Dermatologic surgery. 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