{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:23:25Z","timestamp":1783452205355,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Negative pressure wound therapy combined with timed, cyclical instillation (<jats:styled-content style=\"fixed-case\">NPWTi<\/jats:styled-content>) of topical wound solutions has been recently presented as a new adjunctive modality for treating wounds with signs of infection. Normal saline, antiseptics and antimicrobials all have been proposed in scientific and clinical studies as potentially effective when used with <jats:styled-content style=\"fixed-case\">NPWTi<\/jats:styled-content> for treating heavily infected wounds. This is a prospective clinical study of 131 patients with 131 wounds treated with <jats:styled-content style=\"fixed-case\">NPWTi<\/jats:styled-content> using saline between January 2012 and December 2012 in two orthopaedic centres and one surgical wound healing centre in France. Saline was exclusively used. Results were favourable: in 98% of the cases, the wounds could be closed after debridement and following the use of <jats:styled-content style=\"fixed-case\">NPWTi<\/jats:styled-content>. Mean duration of <jats:styled-content style=\"fixed-case\">NPWTi<\/jats:styled-content> was 12\u00b719\u2009days. This does not preclude the need for treating the biofilm appropriately with more active antibacterial products when biofilm has been documented.<\/jats:p>","DOI":"10.1111\/iwj.12176","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T05:57:18Z","timestamp":1384927038000},"page":"56-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Negative pressure wound therapy with saline instillation: 131 patient case series"],"prefix":"10.1111","volume":"10","author":[{"given":"David","family":"Brinkert","sequence":"first","affiliation":[{"name":"Orthopedic Department Strasbourg University Hospital Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Ali","sequence":"additional","affiliation":[{"name":"Orthopedic Unit Orleans Hospital Orleans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Naud","sequence":"additional","affiliation":[{"name":"College of Pharmacy Montpellier University Hospital Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Maire","sequence":"additional","affiliation":[{"name":"Orthopedic Department Strasbourg University Hospital Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Trial","sequence":"additional","affiliation":[{"name":"Wound Healing Unit Montpellier University Hospital Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"T\u00e9ot","sequence":"additional","affiliation":[{"name":"Wound Healing Unit Montpellier University Hospital Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199706000-00002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199706000-00001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67695-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2196"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000135330.51408.97"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00287.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00460.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225450.12593.12"},{"issue":"1","key":"e_1_2_6_10_1","first-page":"1","article-title":"Consensus statement: a practical guide for managing pressure ulcers with negative pressure wound therapy utilizing vacuum\u2010assisted closure\u2010understanding the treatment algorithm","volume":"21","author":"Baharestani M","year":"2008","journal-title":"Adv Skin Wound Care"},{"issue":"11","key":"e_1_2_6_11_1","first-page":"1","article-title":"Optimizing clinical and cost effectiveness with early intervention of V.A.C. therapy","volume":"54","author":"Baharestani MM","year":"2008","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.00978.x"},{"key":"e_1_2_6_13_1","first-page":"37","article-title":"Combination of subatmospheric pressure dressing and gravity feed antibiotic instillation in the treatment of post\u2010surgical diabetic foot wounds: a case series","volume":"17","author":"Bernstein BH","year":"2005","journal-title":"Wounds"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01014.x"},{"key":"e_1_2_6_15_1","first-page":"309","article-title":"Negative pressure wound therapy with controlled saline instillation (NPWTi) dressing properties and granulation response in vivo","volume":"23","author":"Lessing C","year":"2011","journal-title":"Wounds"},{"key":"e_1_2_6_16_1","first-page":"488","article-title":"Vacuum sealing as treatment of soft tissue damage in open fractures","volume":"96","author":"Fleischmann W","year":"1993","journal-title":"Unfallchirurg"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001130050318"},{"key":"e_1_2_6_18_1","first-page":"56","article-title":"Wound Instillation\u00a0\u2013\u00a0the next step in negative pressure wound therapy. Lessons learned from initial experiences","volume":"50","author":"Wolvos T","year":"2004","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-011-1274-y"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00458.x"},{"key":"e_1_2_6_21_1","first-page":"179","article-title":"The effects of normal saline instillation in conjunction with negative pressure wound therapy (NPWT) on wound healing in a porcine model","volume":"22","author":"Leung BK","year":"2010","journal-title":"Wounds"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00423.x"},{"issue":"1","key":"e_1_2_6_23_1","first-page":"31","article-title":"The impact of V.A.C. Instill in severe soft tissue infections and necrotizing fasciitis","volume":"37","author":"Schintler MV","year":"2009","journal-title":"Infection"},{"key":"e_1_2_6_24_1","first-page":"A42","article-title":"Antimicrobial efficacy of negative pressure wound therapy (NPWT) plus instillation of antimicrobial solutions against mature pseudomonas aeruginosa biofilm","volume":"19","author":"Phillips P","year":"2011","journal-title":"Wound Rep Reg"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T13:45:30Z","timestamp":1700660730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,20]]},"references-count":23,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/iwj.12176"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12176","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,20]]},"assertion":[{"value":"2013-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}