{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:22:01Z","timestamp":1791386521170,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:00:00Z","timestamp":1385596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A chronic wound fails to complete an orderly and timely reparative process and places patients at increased risk for wound complications that negatively impact quality of life and require greater health care expenditure. The role of extracellular matrix (\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    ) is critical in normal and chronic wound repair. Not only is\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    the largest component of the dermal skin layer, but also\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    proteins provide structure and cell signalling that are necessary for successful tissue repair. Chronic wounds are characterised by their inflammatory and proteolytic environment, which degrades the\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    . Human acellular dermal matrices, which provide an\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    scaffold, therefore, are being used to treat chronic wounds. The ideal human acellular dermal wound matrix (HADWM) would support regenerative healing, providing a structure that could be repopulated by the body's cells. Experienced wound care investigators and clinicians discussed the function of\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    , the evidence related to a specific HADWM (Graftjacket\n                    <jats:sup>\u00ae<\/jats:sup>\n                    regenerative tissue matrix, Wright Medical Technology, Inc., licensed by\n                    <jats:styled-content style=\"fixed-case\">KCI USA<\/jats:styled-content>\n                    , Inc., San Antonio,\n                    <jats:styled-content style=\"fixed-case\">TX<\/jats:styled-content>\n                    ), and their clinical experience with this scaffold. This article distills these discussions into an evidence\u2010based and practical overview for treating chronic lower extremity wounds with this HADWM.\n                  <\/jats:p>","DOI":"10.1111\/iwj.12185","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:19:15Z","timestamp":1385597955000},"page":"646-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Human acellular dermal wound matrix: evidence and experience"],"prefix":"10.1111","volume":"12","author":[{"given":"Robert S","family":"Kirsner","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami, Miller School of Medicine  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Bohn","sequence":"additional","affiliation":[{"name":"Trinity Center for Wound Care and Hyperbaric Medicine  Bettendorf IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie R","family":"Driver","sequence":"additional","affiliation":[{"name":"Department of Surgery VA New England Health Care Division  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Sr","given":"Joseph L","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Vascular &amp; Endovascular Surgery, Health Sciences Center University of Arizona  Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian B","family":"Nanney","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Vanderbilt School of Medicine  Nashville TN USA"},{"name":"Department of Cell &amp; Developmental Biology Vanderbilt School of Medicine  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie L","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Podiatry Aventura Hospital and Medical Center  Aventura FL USA"},{"name":"School of Podiatry Barry University  Aventura FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C","family":"Wu","sequence":"additional","affiliation":[{"name":"Dr. William M. Scholl College of Podiatric Medicine Rosalind Franklin University of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,28]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176009"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104315"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00361-7"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00673.x"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-008-9178-z"},{"key":"e_1_2_17_7_1","first-page":"1","article-title":"Extracellular matrix: review of its roles in acute and chronic wounds","author":"Schultz GS","year":"2005","journal-title":"World Wide Wounds"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1996.40404.x"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2012.08.004"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1131-2"},{"key":"e_1_2_17_11_1","unstructured":"Lifecell's History. 2013. URLhttp:\/\/www.lifecell.com\/corporate\/lifecells\u2010history\/[accessed on 3 May2013]."},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(95)93866-I"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000100895.41198.27"},{"key":"e_1_2_17_14_1","volume-title":"Graftjacket regenerative tissue matrix for wounds: instructions for use","author":"KCI USA, Inc","year":"2012"},{"key":"e_1_2_17_15_1","volume-title":"Graftjacket Xpress flowable soft tissue scaffold for wounds: instructions for use","author":"KCI USA, Inc","year":"2012"},{"key":"e_1_2_17_16_1","first-page":"72","article-title":"Comparison of dermal substitutes in wound healing utilizing a nude mouse model","volume":"4","author":"Truong AT","year":"2005","journal-title":"J Burns Wounds"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SAP.0000044252.76804.6B"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182450ae5"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2007.0316"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200103000-00016"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00585.x"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2006.00209.x"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-20040102-14"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000323532.98003.26"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4801.2005.00099.x"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1938640009333474"},{"key":"e_1_2_17_27_1","first-page":"44","article-title":"Classification of diabetic foot wounds","volume":"43","author":"Lavery LA","year":"1997","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1994.20305.x"},{"key":"e_1_2_17_29_1","first-page":"65","article-title":"Foot ulcers in the diabetic patient, prevention and treatment","volume":"3","author":"Wu SC","year":"2007","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.2119\/2006-00054.Brem"},{"key":"e_1_2_17_32_1","unstructured":"Jaslow R. Diabetes strikes \u201cstaggering\u201d 366 million people.2011. URLhttp:\/\/www.cbsnews.com\/8301\u2010504763_162\u201020105533\u201010391704.html[accessed on 15 April 2013]."},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-006-0076-x"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2007.16.4.27025"},{"key":"e_1_2_17_35_1","first-page":"47","article-title":"Wound bed preparation and the role of enzymes: a case for multiple actions of therapeutic agents","volume":"14","author":"Falanga V","year":"2002","journal-title":"Wounds"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-92-1-34"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10603.x"},{"key":"e_1_2_17_38_1","first-page":"22","article-title":"Managing wounds in a managed care environment: the integration concept","volume":"44","author":"Ennis WJ","year":"1998","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_17_39_1","first-page":"61","article-title":"Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group","volume":"183","author":"Steed DL","year":"1996","journal-title":"J Am Coll Surg"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00485.x"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00619.x"},{"key":"e_1_2_17_42_1","volume-title":"V.A.C. Therapy Clinical Guidelines: a reference source for clinicians","author":"Kinetic Concepts, Inc","year":"2012"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000222891.74489.33"},{"key":"e_1_2_17_44_1","first-page":"409","volume-title":"Diabetes in America","author":"Reiber GE","year":"1995"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.03.009"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70036-8"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.9.1333"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.8.2305"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.06.003"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.290"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1701"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:53:11Z","timestamp":1696265591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,28]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/iwj.12185"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12185","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,28]]},"assertion":[{"value":"2013-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}