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Hence, innovative therapies are needed to decrease the morbidity and mortality. Because of the proven therapeutic effects in other fields, mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">MSCs<\/jats:styled-content>) might be considered as a promising alternative to treat <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content>. Numerous documents demonstrate that <jats:styled-content style=\"fixed-case\">MSCs<\/jats:styled-content> can exert multiple functions, such as engraftment, differentiation and immunoregulation, but now the key researches are concentrated on paracrine factors secreted by <jats:styled-content style=\"fixed-case\">MSCs<\/jats:styled-content> that can mediate endothelial and epithelial permeability, increase alveolar fluid clearance and other potential mechanisms. This review aimed to review the current researches in terms of the effects of <jats:styled-content style=\"fixed-case\">MSCs<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content> and to analyse these paracrine factors, as well as to predict the potential directions and challenges of the application in this field.<\/jats:p>","DOI":"10.1111\/iwj.12202","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T09:30:40Z","timestamp":1388050240000},"page":"114-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Paracrine factors from mesenchymal stem cells: a proposed therapeutic tool for acute lung injury and acute respiratory distress syndrome"],"prefix":"10.1111","volume":"11","author":[{"given":"Jiwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Nanfang Hospital, Southern Medical University Guangzhou P. 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