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Bioflavonoids, such as diosmin and other compounds, appear to have several provessel function activities including anti\u2010inflammatory, antioxidant and phlebotonic effects and are widely used in the treatment of chronic venous disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>)\u2010related problems.<\/jats:p><jats:p>In this article, we evaluated the effects of Axaven<jats:sup>\u00ae<\/jats:sup>, a new nutraceutical on both clinical and molecular parameters in patients with <jats:styled-content style=\"fixed-case\">CVUs<\/jats:styled-content>.<\/jats:p><jats:p>During the study period, 83 patients with <jats:styled-content style=\"fixed-case\">CVUs<\/jats:styled-content> of both sexes were enrolled and divided into two groups: group A (treated group): 25 females and 19 males (median age is 67\u00b77 years) received standard treatment (compression therapy and surgical correction of superficial venous incompetence) + Axaven<jats:sup>\u00ae<\/jats:sup> once a day for 8 months as adjunctive treatment.<\/jats:p><jats:p>Group B (control group): 24 females and 15 males (median age is 65\u00b72 years) were treated only with basic treatment according to their clinical conditions.<\/jats:p><jats:p>In our study, the administration of Axaven<jats:sup>\u00ae<\/jats:sup> in patients with <jats:styled-content style=\"fixed-case\">CVUs<\/jats:styled-content> was able to decrease inflammatory cytokines, <jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>, inducing an improvement of both symptoms with an increase of the speed of wound healing.<\/jats:p>","DOI":"10.1111\/iwj.12240","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T02:16:37Z","timestamp":1393380997000},"page":"88-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Effects of a new nutraceutical substance on clinical and molecular parameters in patients with chronic venous ulceration"],"prefix":"10.1111","volume":"13","author":[{"given":"Raffaele","family":"Serra","sequence":"first","affiliation":[{"name":"Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Graecia of Catanzaro  Catanzaro Italy"},{"name":"Department of Surgical and Medical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Grande","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Butrico","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Buffone","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco G","family":"Cali\u00f2","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery S. 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