{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:22Z","timestamp":1790740642715,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this study is to determine if weekly application of dehydrated human amnion\/chorion membrane allograft reduce time to heal more effectively than biweekly application for treatment of diabetic foot ulcers.<\/jats:p>\n                  <jats:p>This was an institutional review board\u2010approved, registered, prospective, randomised, comparative, non\u2010blinded, single\u2010centre clinical trial. Patients with non\u2010infected ulcers of \u2265\u20094\u2009weeks duration were included for the study. They were randomised to receive weekly or biweekly application of allograft in addition to a non\u2010adherent, moist dressing with compressive wrapping. All wounds were offloaded. The primary study outcome was mean time to healing.<\/jats:p>\n                  <jats:p>\n                    Overall, during the 12\u2010week study period, 92\u00b75% (37\/40) ulcers completely healed. Mean time to complete healing was 4\u00b71\u2009\u00b1\u20092\u00b79 versus 2\u00b74\u2009\u00b1\u20091\u00b78\u2009weeks (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090\u00b7039) in the biweekly versus weekly groups, respectively. Complete healing occurred in 50% versus 90% by 4\u2009weeks in the biweekly and weekly groups, respectively (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090\u00b7014). Number of grafts applied to healed wounds was similar at 2\u00b74\u2009\u00b1\u20091\u00b75 and 2\u00b73\u2009\u00b1\u20091\u00b78 for biweekly versus weekly groups, respectively (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090\u00b7841).\n                  <\/jats:p>\n                  <jats:p>These results validate previous studies showing that the allograft is an effective treatment for diabetic ulcers and show that wounds treated with weekly application heal more rapidly than with biweekly application. More rapid healing may decrease clinical operational costs and prevent long\u2010term medical complications.<\/jats:p>","DOI":"10.1111\/iwj.12242","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T12:39:42Z","timestamp":1393245582000},"page":"122-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["A prospective, randomised comparative study of weekly versus biweekly application of dehydrated human amnion\/chorion membrane allograft in the management of diabetic foot ulcers"],"prefix":"10.1111","volume":"11","author":[{"given":"Charles M","family":"Zelen","sequence":"first","affiliation":[{"name":"Department of Clinical Research, Professional Education and Research Institute, Inc. Roanoke VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Serena","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, SerenaGroup Wound and Hyperbaric Centers Warren PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Podiatric Medicine, Barry University School of Podiatric Medicine Miami Shores FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,21]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"HoC TranK HuxM SibbaldG CampbellK. Artificial skin grafts in chronic wound care: a meta\u2010analysis of clinical efficacy and a review of cost\u2010effectiveness [Tech. Rep. 52]. Ottawa: Canadian Coordinating Office for Health Technology Assessment;2005."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2425"},{"key":"e_1_2_5_4_1","unstructured":"CDC2011National Estimates\u00a0\u2013\u00a02011 National Diabetes Fact Sheet\u00a0\u2013\u00a0Publications\u00a0\u2013\u00a0Diabetes DDT. URLhttp:\/\/www.cdc.gov\/diabetes\/pubs\/estimates11.htm[accessed on 16 December 2013]."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_5_6_1","first-page":"44","article-title":"A post\u2010hoc analysis of reduction in diabetic foot ulcer size at 4\u2009weeks as a predictor of healing by 12\u2009weeks","volume":"56","author":"Snyder RJ","year":"2010","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.5.692"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9021"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00860.x"},{"key":"e_1_2_5_11_1","volume-title":"2011 Data Points Publication Series [Internet]","author":"Margolis DJ","year":"2011"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(98)80044-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.9.1333"},{"key":"e_1_2_5_14_1","first-page":"299","article-title":"Scientific and clinical support for the use of dehydrated amniotic membrane in wound management","volume":"24","author":"Fetterolf DE","year":"2012","journal-title":"Wounds"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12140"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12097"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.7.347"},{"key":"e_1_2_5_18_1","article-title":"Dehydrated human amnion\/chorion membrane allografts in patients with chronic diabetic foot ulcers: a long\u2010term follow\u2010up study","author":"Zelen CM","year":"2013","journal-title":"Wound Medicine"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2012.21.6.290"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12035"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.7547\/0003-0538-104.2.198"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.4.350"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1701"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.290"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1999.00335.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000288217.83128.f3"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000358639.45784.cd"},{"key":"e_1_2_5_28_1","article-title":"Risk factors associated with healing chronic diabetic foot ulcers: the importance of hyperglycemia","volume":"52","author":"Marston WA","year":"2006","journal-title":"Ostomy Wound Manage"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.12242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:31:12Z","timestamp":1696257072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,21]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/iwj.12242"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12242","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,21]]},"assertion":[{"value":"2013-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}