{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:41:31Z","timestamp":1791693691584,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Keraplast Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene (<jats:styled-content style=\"fixed-case\">KRT<\/jats:styled-content>) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of <jats:styled-content style=\"fixed-case\">KRT17<\/jats:styled-content> has been shown to delay wound closure. In addition, downregulation of <jats:styled-content style=\"fixed-case\">KRT6<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">KRT16<\/jats:styled-content> in non\u2010healing chronic venous ulcers suggests that deregulation of keratin expression contributes to non\u2010healing phenotype. A sample of 45 chronic wounds of mixed aetiologies presenting in 31 patients were treated with keratin\u2010based novel topical wound healing products. Thirty\u2010seven wounds or 82% of wounds were either healed or reduced in size of &gt;50% during treatment, with 29 (64%) healing completely and an additional 8 wounds experiencing 50% wound size reduction or greater. Of the wounds that responded, 15 required antimicrobial treatment during their course of treatment, suggesting that keratin dressing treatment should be interrupted briefly and then restarted when wound infection occur.<\/jats:p>","DOI":"10.1111\/iwj.12245","type":"journal-article","created":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T17:41:39Z","timestamp":1393695699000},"page":"110-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The use of keratin\u2010based wound products on refractory wounds"],"prefix":"10.1111","volume":"13","author":[{"given":"Annette T","family":"Batzer","sequence":"first","affiliation":[{"name":"Rogue Regional Medical Center Advanced Wound Center  Medford OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Marsh","sequence":"additional","affiliation":[{"name":"Keraplast Research  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S","family":"Kirsner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_2_7_3_1","volume-title":"Dermatologic surgery","author":"Lamel S","year":"2014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.14.5248-5255.2000"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01327.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2741\/2277"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.08.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04659"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2012.01505.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00768.x"},{"key":"e_1_2_7_12_1","first-page":"e45","article-title":"Do functional keratin dressings accelerate epithelialisation in human partial thickness wounds? 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