{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:28:30Z","timestamp":1790843310513,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T00:00:00Z","timestamp":1399420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30872686"],"award-info":[{"award-number":["30872686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human hypertrophic scar undergoes hyperplasia and regression during progression. This study aimed to investigate whether fibroblasts in scar tissue undergo biological changes during the formation and regression of human hypertrophic scar. Using 32 scar samples, we measured collagen production by Masson's staining and the expression levels of transforming growth factor (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>)\u2010\u03b21 and vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) by immunohistochemistry. In addition, fibroblasts from scar tissue were isolated and cultured, and total <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was extracted for measurement of <jats:italic><jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21<\/jats:italic>, <jats:italic><jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content><\/jats:italic> and collagen transcript levels by reverse transcription\u2010polymerase chain reaction (<jats:styled-content style=\"fixed-case\">RT\u2010PCR<\/jats:styled-content>). Masson's staining showed that the number of fibroblasts and microvessels increased gradually in early and proliferative scars but decreased in regressive scars. Immunohistochemistry revealed that the expression of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21 and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> increased in early scars, peaked in proliferative scars and decreased in regressive scars. Moreover, the expression of <jats:italic><jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21<\/jats:italic>, <jats:italic><jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content><\/jats:italic>, collagen I and collagen <jats:styled-content style=\"fixed-case\">III mRNAs<\/jats:styled-content> also increased in early and proliferative scars and decreased significantly in regressive scars. Dynamic changes in fibroblast biology correlated with the formation and progression of hypertrophic scar.<\/jats:p>","DOI":"10.1111\/iwj.12283","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T08:21:42Z","timestamp":1399450902000},"page":"257-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Dynamic biological changes in fibroblasts during hypertrophic scar formation and regression"],"prefix":"10.1111","volume":"13","author":[{"given":"Qing","family":"Chun","sequence":"first","affiliation":[{"name":"Shanghai Burns Institute, Ruijin Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"ZhiYong","sequence":"additional","affiliation":[{"name":"Shanghai Burns Institute, Ruijin Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Fei","sequence":"additional","affiliation":[{"name":"Shanghai Burns Institute, Ruijin Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"XiQiao","sequence":"additional","affiliation":[{"name":"Shanghai Burns Institute, Ruijin Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.34067.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12606979"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199408000-00005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197910000-00007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.9.4604"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000166282.01034.8f"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000034241.55602.AD"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.486"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-2-13"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.01.032"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06698.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2008.08.007"},{"issue":"3","key":"e_1_2_6_14_1","first-page":"371","article-title":"Structure of collagen nodule from hypertrophic scars and keloids","author":"CW K","year":"1981","journal-title":"Scan Electron Microsc"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(85)90045-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-1-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.4.1297-1310.2001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.6.1834-1843.2002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.047"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01124.x"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12283","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:49:02Z","timestamp":1696268942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,7]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/iwj.12283"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12283","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,7]]},"assertion":[{"value":"2014-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}