{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:36:13Z","timestamp":1762540573281},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mixed arterial and venous ulcers of the lower limbs are present in around 15\u201330% of patients with chronic venous ulcers (<jats:styled-content style=\"fixed-case\">CVUs<\/jats:styled-content>) and are considered difficult\u2010to\u2010heal wounds. The aim of this study was to evaluate the results of the treatment of mixed arterial and venous ulcers of the lower limbs with prostaglandin <jats:styled-content style=\"fixed-case\">E1<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PGE1<\/jats:styled-content>) infusion. This study was carried out in 48 consecutive patients. Patients who showed intolerability to <jats:styled-content style=\"fixed-case\">PGE1<\/jats:styled-content>, and patients with peripheral neuropathy, blood or systemic diseases, malignancy and acute wound infections or necrotic tissue on the wound bed were excluded. The patients were separated at random into two main groups: group I (25 patients) received standard treatment and <jats:styled-content style=\"fixed-case\">PGE1<\/jats:styled-content> infusion. Group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (23 patients) received only standard treatment. Pre\u2010treatment data indicated the area of ulceration. The number of healed ulcers and the variation in the area of ulceration were considered as endpoints. The endpoints were noticed after 120 days from the beginning of treatment. Healing occurred in 80% of limbs of group I and in 52\u00b72% of limbs of group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> patients. The average reduction in area was 92% versus 60% in patients of group I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, respectively. During the whole treatment period, the incidence of adverse events was 8% in group I: there was one case of headache and one case of headache and hypotension combined. No side effects were recorded in patients of group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. In conclusion, <jats:styled-content style=\"fixed-case\">PGE1<\/jats:styled-content> infusion is a determinant in the reduction of the healing time of mixed ulcers of the lower limbs.<\/jats:p>","DOI":"10.1111\/iwj.12334","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T09:45:51Z","timestamp":1407231951000},"page":"625-629","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of prostaglandin <scp>E1<\/scp> in patients with mixed arterial and venous ulcers of the lower limbs"],"prefix":"10.1111","volume":"13","author":[{"given":"Giovanni","family":"De Caridi","sequence":"first","affiliation":[{"name":"Cardiovascular and Thoracic Department, \u2018Policlinico G. Martino\u2019 Hospital University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mafalda","family":"Massara","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department, \u2018Policlinico G. Martino\u2019 Hospital University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Stilo","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department, \u2018Policlinico G. Martino\u2019 Hospital University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department, \u2018Policlinico G. Martino\u2019 Hospital University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Grande","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Butrico","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"de Franciscis","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro Italy"},{"name":"Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science University Magna Graecia of Catanzaro  Catanzaro Italy"},{"name":"Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780729"},{"key":"e_1_2_5_3_1","first-page":"347","article-title":"Ulcer\u00e8s de jambe d'origine veineuse","volume":"37","author":"Cornu\u2010Thenard A","year":"1984","journal-title":"Phlebologie"},{"key":"e_1_2_5_4_1","first-page":"83","article-title":"Chronic venous disorders of the leg: epidemiology, outcome, diagnosis and management. Summary on an evidence\u2010based report of the VEINES task force","volume":"18","author":"Kurz X","year":"1999","journal-title":"Int Angiol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1996.02099.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(88)90464-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12042"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.11.036"},{"key":"e_1_2_5_9_1","first-page":"57","article-title":"Chronic venous disease is more aggressive in patients with varicocele","volume":"14","author":"Serra R","year":"2013","journal-title":"Acta Phlebol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2012.03.016"},{"key":"e_1_2_5_11_1","first-page":"61","article-title":"Quercetin and chronic venous ulceration of the lower limbs","volume":"14","author":"Gasbarro V","year":"2013","journal-title":"Acta Phlebol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12071"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.04.008"},{"key":"e_1_2_5_14_1","article-title":"Chronic venous ulceration of the lower limbs and thrombosis","author":"Franciscis S","year":"2014","journal-title":"Acta Phlebol"},{"key":"e_1_2_5_15_1","first-page":"1","article-title":"The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and ulcers of lower limbs","volume":"8","author":"Serra R","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780836"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80223-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1524-4725.1997.tb00759.x","article-title":"Pericapillary fibrin cuffs in venous disease. A reappraisal","volume":"23","author":"Van der Scheur M","year":"1997","journal-title":"Dermatol Surg"},{"key":"e_1_2_5_19_1","first-page":"115","article-title":"Pulmonary embolism, metalloproteinases and neutrophil gelatinase associated lipocalin","volume":"14","author":"Busceti MT","year":"2013","journal-title":"Acta Phlebol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.07.026"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12181"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12035"},{"key":"e_1_2_5_23_1","first-page":"99","article-title":"The effects of minocycline on extracellular matrix in patients with chronic venous leg ulcers","volume":"14","author":"Serra R","year":"2013","journal-title":"Act Phlebol"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12240"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12077"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12225"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.01.011"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2014.03.022"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.05.052"},{"key":"e_1_2_5_30_1","article-title":"Effects of glucocorticoids and TNF\u2010alfa inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis","author":"Serra R","year":"2014","journal-title":"J Pharmacol Pharmacother"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/02688697.2014.913777"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/839094"},{"key":"e_1_2_5_33_1","first-page":"368","article-title":"The effect of revascularization procedures on healing of mixed arterial and venous leg ulcers","volume":"32","author":"Georgopoulos S","year":"2013","journal-title":"Int Angiol"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2010.09.006"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(98)80056-7"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12003"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12085"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6730.972"},{"key":"e_1_2_5_39_1","first-page":"CD001733","article-title":"Pentoxifylline for treating venous leg ulcers","volume":"12","author":"Jull AB","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_40_1","first-page":"11","article-title":"Treatment of extensive trophic ulcers of the lower extremities","volume":"50","author":"Mishchenko EN","year":"2002","journal-title":"Klin Kir"},{"key":"e_1_2_5_41_1","first-page":"545","article-title":"Treatment of hypertensive venous leg ulcers with nifedipine","volume":"17","author":"Nicolova K","year":"1995","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"e_1_2_5_42_1","first-page":"145","article-title":"Treatment of venous leg ulcers with topical iloprost: a placebo\u2010controlled study","volume":"23","author":"Werner\u2010Schlenzka H","year":"1994","journal-title":"Vasa"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.03.040"},{"key":"e_1_2_5_44_1","first-page":"109","article-title":"Haemodynamic surgery versus conventional surgery in chronic venous disease: a multicenter retrospective study","volume":"14","author":"Franciscis S","year":"2013","journal-title":"Acta Phlebol"},{"key":"e_1_2_5_45_1","first-page":"1407","article-title":"A nonlinear lumped parameters model to analyze the dynamics of venous reflux","volume":"2008","author":"Fragomeni G","year":"2008","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_2_5_46_1","first-page":"13","article-title":"A new photographic computerized measurement system for chronic wound assessment","volume":"15","author":"Franciscis S","year":"2014","journal-title":"Acta Phlebol"},{"key":"e_1_2_5_47_1","first-page":"480","article-title":"Leg ulcers \u2013 causes and management","volume":"35","author":"Dean S","year":"2006","journal-title":"Aust Fam Physician"},{"key":"e_1_2_5_48_1","first-page":"172","article-title":"Therapeutic success in refractory ulcers of the lower extremity in intensive prostavasin therapy","volume":"33","author":"Meyer P","year":"1991","journal-title":"Vasa Suppl"},{"issue":"1","key":"e_1_2_5_49_1","first-page":"65","article-title":"Comparison of combined treatment for venous ulcers in postphlebitic syndrome and use of PGE\u20101\u2010\u2010introductory remarks","volume":"50","author":"Lazarkiewicz B","year":"1997","journal-title":"Wiad Lek"},{"key":"e_1_2_5_50_1","first-page":"39","article-title":"Intravenous prostaglandin E1 in the treatment of venous ulcers\u2010\u2010a double\u2010blind, placebo\u2010controlled trial","volume":"28","author":"Rudofsky G","year":"1989","journal-title":"Vasa Suppl"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1556\/OH.2011.29277"},{"issue":"1","key":"e_1_2_5_52_1","first-page":"CD006544","article-title":"Prostanoids for critical limb ischaemia","author":"Ruffolo AJ","year":"2010","journal-title":"Cochrane Database Syst Rev"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12334","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T21:48:27Z","timestamp":1696196907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/iwj.12334"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12334","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]},"assertion":[{"value":"2014-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}