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Matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content>), neutrophil gelatinase\u2010associated lipocalin (<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>) and cytokines are biomarkers involved in several vascular complications. The aim of this study was to evaluate the role of <jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> and inflammatory cytokines in I\/R syndrome. We conducted an open label, multicentric, parallel group study, between January 2010 and December 2013. Patients with acute limb ischaemia were enrolled in this study and were divided into two groups: (i) those subjected to fasciotomy and (ii) those not subjected to fasciotomy, according to the onset of compartment syndrome. Plasma and tissue values of <jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> as well as plasma cytokines were evaluated. <jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> and cytokine levels were higher in patients with compartment syndrome. Biomarkers evaluated in this study may be used in the future as predictors of I\/R injury severity and its possible evolution towards post\u2010reperfusion syndrome.<\/jats:p>","DOI":"10.1111\/iwj.12392","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T16:35:19Z","timestamp":1417624519000},"page":"854-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biomarkers in post\u2010reperfusion syndrome after acute lower limb ischaemia"],"prefix":"10.1111","volume":"13","author":[{"given":"Stefano","family":"de Franciscis","sequence":"first","affiliation":[{"name":"Interuniversity Center of Phlebolymphology (CIFL) University Magna Graecia of Catanzaro  Catanzaro Italy"},{"name":"Department of Medical and Surgical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"De Caridi","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafalda","family":"Massara","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Buffone","sequence":"additional","affiliation":[{"name":"Interuniversity Center of Phlebolymphology (CIFL) University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco G","family":"Cali\u00f2","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery S. 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