{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T12:17:42Z","timestamp":1772540262453,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,25]],"date-time":"2015-01-25T00:00:00Z","timestamp":1422144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of bilirubin, a well\u2010known and powerful antioxidant, has gained popularity in recent years because of its role in the prevention of ischaemic heart disease in patients with Gilbert's syndrome. We investigate the effects of bilirubin on ischaemia\u2010reperfusion (I\/R) injury using a rat perforator flap model.<\/jats:p><jats:p>Forty\u2010eight rats were randomly divided into two groups: experimental (bilirubin) group (<jats:italic>n<\/jats:italic> = 24) and control group (<jats:italic>n<\/jats:italic> = 24). In each group, elevated bilateral deep inferior epigastric perforator (<jats:styled-content style=\"fixed-case\">DIEP<\/jats:styled-content>) flaps were created. The right (no ischaemia side) and left (ischaemia side) <jats:styled-content style=\"fixed-case\">DIEP<\/jats:styled-content> flaps were separated according to the presence of ischaemia induction. Ischaemia was induced in anaesthetised rats by perforator clamping for 15 or 30 minutes. After surgery, the flap survival was assessed daily on postoperative days 0 to 5, and overall histological changes of <jats:styled-content style=\"fixed-case\">DIEP<\/jats:styled-content> flaps above the perforator were analysed at postoperative day 5.<\/jats:p><jats:p>The flap survival rate in the bilirubin group was significantly higher than that in the control group at the ischaemia side following perforator clamping for 15 or 30 minutes (93\u00b742 \u00b1 4\u00b748% versus 89\u00b763 \u00b1 3\u00b798%, <jats:italic>P<\/jats:italic> = 0\u00b7002; and 83\u00b796 \u00b1 4\u00b723% versus 36\u00b746 \u00b1 6\u00b738%, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001, respectively). The difference in flap survival between the two groups was the most prominent on the ischaemic side following 30 minutes of perforator clamping.<\/jats:p><jats:p>From a morphologic perspective, pre\u2010treatment with bilirubin was found to alleviate perforator flap necrosis caused by I\/R injury in this experimental rat model.<\/jats:p>","DOI":"10.1111\/iwj.12396","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T01:23:40Z","timestamp":1422235420000},"page":"870-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bilirubin provides perforator flap protection from ischaemia\u2010reperfusion injury in a rat model: a preliminary result"],"prefix":"10.1111","volume":"13","author":[{"given":"Sung Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Medicine Konkuk University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Kyun","family":"Rah","sequence":"additional","affiliation":[{"name":"Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, College of Medicine Yonsei University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosep","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Pathology The Catholic University of Korea, Yeouido St. Mary's Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine Konkuk University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hwan","family":"Park","sequence":"additional","affiliation":[{"name":"Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, College of Medicine Yonsei University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22247"},{"key":"e_1_2_6_3_1","first-page":"559","article-title":"The effect of Gilbert's syndrome on the dispersions of QT interval and P\u2010wave: an observational study","volume":"13","author":"Cure E","year":"2013","journal-title":"Anadolu Kardiyol 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