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In this study, we introduce full\u2010thickness micro skin grafts in the ulcer, a surgical technique known as a \u2018nested graft\u2019, which gave encouraging results leading to complete wound healing in all patients. The assessment of fibroblast cultures taken from the wound before and after treatment and comparison with fibroblasts from healthy skin showed that the fibroblasts taken from the ulcer after the nested graft treatment acquire morpho\u2010functional characteristics overlapping those of fibroblasts from healthy skin. This surgical approach is, therefore, able to lead to the healing of chronic ulcers through the de\u2010senescence of the fibroblasts.<\/jats:p>","DOI":"10.1111\/iwj.12415","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T15:49:03Z","timestamp":1426866543000},"page":"1104-1110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The nested graft acts by inducing the process of de\u2010senescence of the fibroblasts in chronic venous ulcers"],"prefix":"10.1111","volume":"13","author":[{"given":"Giulio","family":"Gualdi","sequence":"first","affiliation":[{"name":"Department of Dermatology Spedali civili di Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Crotti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Spedali civili di Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Monari","sequence":"additional","affiliation":[{"name":"Department of Dermatology Spedali civili di Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piergiacomo","family":"Calzavara\u2010Pinton","sequence":"additional","affiliation":[{"name":"Department of Dermatology Spedali civili di Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Vitali","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. 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