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An untreated alpha\u20101\u2010antitrypsin (AAT) deficiency in the patient's medical history, known since 20\u2009years and clinically apparent as a mild to moderate chronic obstructive pulmonary disease, was eventually found to be at its origin. Further clinical work\u2010up showed AAT serum levels below 30% of the lower reference value; phenotype testing showed a <jats:styled-content style=\"fixed-case\">ZZ<\/jats:styled-content> phenotype and a biopsy taken from the wound area showed the characteristic, disease\u2010related histological pattern of necrotising panniculitits. Augmentation therapy with plasma AAT was initiated and within a few weeks, rapid and adequate would healing was observed. AAT deficiency is an uncommon but clinically significant, possible cause of wound healing disturbances. An augmentation therapy ought to be considered in affected patients during the perioperative period.<\/jats:p>","DOI":"10.1111\/iwj.12419","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:08:50Z","timestamp":1427414930000},"page":"601-604","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Severe postoperative wound healing disturbance in a patient with alpha\u20101\u2010antitrypsin deficiency: the impact of augmentation therapy"],"prefix":"10.1111","volume":"12","author":[{"given":"Marionna","family":"Cathomas","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine University Hospital of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sch\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine University Hospital of Bern  Bern 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