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Comparing with conventional corticosteroid injections, verapamil could improve the appearance of keloid and hypertrophic scars, and is associated with a lower incidence of adverse effects. Is verapamil an effective alternative modality in the prevention and treatment of keloid and hypertrophic scars? The aim of this study was to assess the effectiveness of verapamil in preventing and treating keloid and hypertrophic scars. Searches were conducted in Medline, <jats:styled-content style=\"fixed-case\">EMbase<\/jats:styled-content> and Cochrane databases from 1974 to January 2015. The selection of articles was limited to human subjects. Five randomised controlled trials (<jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>) or cluster\u2010randomised trials or controlled clinical trials (<jats:styled-content style=\"fixed-case\">CCTs<\/jats:styled-content>) comparing the efficacy of verapamil with conventional treatments were identified. The results showed that verapamil could improve keloid and hypertrophic scars, and was not significantly different from conventional corticosteroid injections. Few adverse effects were observed. However, this result should be considered carefully, as most of the included studies have a high risk of bias because of issues with randomization, allocation concealment, blinding, incomplete outcomes and selective reporting. In conclusion, verapamil could act as an effective alternative modality in the prevention and treatment of keloid and hypertrophic scars. More high\u2010quality, multiple\u2010centre, large\u2010sample (<jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>) are required to define the role of verapamil in preventing and treating keloid and hypertrophic scars.<\/jats:p>","DOI":"10.1111\/iwj.12455","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T02:34:54Z","timestamp":1431484494000},"page":"461-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Role of verapamil in preventing and treating hypertrophic scars and keloids"],"prefix":"10.1111","volume":"13","author":[{"given":"Ru","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery West China Hospital of Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Mao","sequence":"additional","affiliation":[{"name":"Pediatric Department The People's 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