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Matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content>) seem to be involved in atherosclerosis, <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content>. Aim of this study was to evaluate variations in <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> serum levels in patients affected by <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content>, before and after lower limb surgical revascularisation through prosthetic or venous bypass. A total of 29 patients (7 females and 22 males, mean age 73\u00b74 years, range 65\u201383 years) suffering from <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content> and submitted to lower extremity bypass (<jats:styled-content style=\"fixed-case\">LEB<\/jats:styled-content>) in our Institution were recruited. Seven patients (group I) underwent <jats:styled-content style=\"fixed-case\">LEB<\/jats:styled-content> using synthetic polytetrafluoroethylene (<jats:styled-content style=\"fixed-case\">PTFE<\/jats:styled-content>) graft material and 22 patients (group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) underwent <jats:styled-content style=\"fixed-case\">LEB<\/jats:styled-content> using autogenous veins. Moreover, 30 healthy age\u2010sex\u2010matched subjects were also enrolled as controls (group <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>). We documented significantly higher serum <jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content> levels (<jats:italic>P<\/jats:italic> &lt; 0\u00b701) in patients with <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content> (groups I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) with respect to control group (group <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>). Finally, five patients with <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content> (17\u00b72%) showed poor outcomes (major amputations or death), and enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) test showed very high levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108. <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> serum levels seem to be able to predict the clinical outcomes of patients with <jats:styled-content style=\"fixed-case\">CLI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iwj.12464","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T16:42:28Z","timestamp":1432744948000},"page":"493-499","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Matrix 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