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The present study was designed to determine the effect of systemic and topical administration of piracetam and nimodipine on full\u2010thickness skin burn wound healing. A total of 36 New Zealand male rabbits were divided into six groups. Full\u2010thickness skin burns were produced in all the groups, except the control group. Piracetam was administered systemically (piracetam\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) and topically (piracetam\u2010C) for 14 days, and nimodipine was administered systemically (nimodipine\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) and topically (nimodipine\u2010C) over the burn wounds for 14 days. The sham group underwent burn injury but was not administered any drug. After 21 days, gross examination and histopathological analysis were performed and the results were compared statistically. Nimodipine\u2010C and nimodipine\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> had no effect on burn wound healing. However, both piracetam\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and piracetam\u2010C significantly enhanced the healing of the full\u2010thickness skin burn wounds, although the latter was more effective, useful and practical in burn wound healing. The histopathological features of the wounds in the piracetam\u2010C group were closer to those of the control group than those of the other groups. Piracetam\u2010C rather than piracetam\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> may promote full\u2010thickness burn wound healing in rabbits.<\/jats:p>","DOI":"10.1111\/iwj.12478","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T13:52:51Z","timestamp":1437400371000},"page":"563-571","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of piracetam and nimodipine on full\u2010thickness skin burns in rabbits"],"prefix":"10.1111","volume":"13","author":[{"given":"Elif","family":"Sari","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery Kirikkale University Faculty of Medicine  Kirikkale Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gungor C","family":"Dincel","sequence":"additional","affiliation":[{"name":"Gumushane University, Siran Mustafa Beyaz Vocational School 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