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At each visit, blood sample was collected to evaluate plasma levels of matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20101,\u20102,\u20103,\u20107,\u20108 and \u20109 <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> inhibitors, <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101,\u20102, neutrophil gelatinase\u2010associated lipocalin (<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>) and cytokines <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106.<\/jats:p><jats:p>Analysis included 201 patients [86 males (42\u00b779%) and 115 females (57\u00b721%); average age 56 \u00b1 7 years].<\/jats:p><jats:p>Of the 201 patients, 47 (23\u00b738%; 21 males, 26 females) developed <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> during the follow\u2010up period.<\/jats:p><jats:p>The control group was made up of 60 individuals without <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> (22 males and 38 females).<\/jats:p><jats:p>High plasma levels of <jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> and cytokines were recorded during the acute phase after <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>. Moreover, patients with <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> showed higher levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 with respect to patients without <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content>.<\/jats:p><jats:p>There is a close relationship between <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>, the individual risk of <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> and specific biomarkers such as <jats:styled-content style=\"fixed-case\">MMPs<\/jats:styled-content> and other related molecules, which may help guide prevention and therapy based on the patient's individual risk profile, and has to be studied in future.<\/jats:p>","DOI":"10.1111\/iwj.12489","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T01:46:46Z","timestamp":1443145606000},"page":"1237-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Plasma <scp>MMP<\/scp> and <scp>TIMP<\/scp> evaluation in patients with deep venous thrombosis: could they have a predictive role in the development of post\u2010thrombotic syndrome?"],"prefix":"10.1111","volume":"13","author":[{"given":"Stefano","family":"de Franciscis","sequence":"first","affiliation":[{"name":"Interuniversity Center of Phlebolymphology (CIFL). 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