{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:54:04Z","timestamp":1773694444549,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T00:00:00Z","timestamp":1443052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>Venous leg ulcers (VLUs<\/jats:styled-content>) have higher tumor necrosis factor\u2010\u03b1 (TNF<\/jats:styled-content>\u2010\u03b1) levels compared with normal skin. Refractory VLUs<\/jats:styled-content> of long duration have higher TNF<\/jats:styled-content>\u2010\u03b1 levels compared with VLUs<\/jats:styled-content> of shorter duration. As up to 75% of VLUs<\/jats:styled-content> fail to heal with standard care, we sought to evaluate the role of anti\u2010TNF<\/jats:styled-content>\u2010\u03b1 therapy for patients with refractory VLUs<\/jats:styled-content>. Evaluable data were obtained in four of five subjects with recalcitrant VLUs<\/jats:styled-content> treated with 80 mg of subcutaneous adalimumab at week 0 and with 40 mg at week 2 along with compression therapy and were followed\u2010up for 6 weeks. Wound biopsies taken at weeks 0 and 4 were stained with anti\u2010TNF<\/jats:styled-content>\u2010\u03b1 antibodies. Average 4\u2010week percent wound size reduction was 20.5% \u00b1 6.4%. Two patients had wound size reduction more than 25%, and their percent wound size reduction correlated to percent TNF<\/jats:styled-content>\u2010\u03b1 staining score reductions (P<\/jats:italic><\/jats:styled-content> = 0.02, R<\/jats:italic>2<\/jats:sup><\/jats:styled-content> = 0.999). VLU TNF<\/jats:styled-content>\u2010\u03b1 level decrease 4 weeks post\u2010adalimumab treatment correlated with wound healing.<\/jats:p>","DOI":"10.1111\/iwj.12497","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T09:44:15Z","timestamp":1443087855000},"page":"963-966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Adalimumab treatment leads to reduction of tissue tumor necrosis factor\u2010alpha correlated with venous leg ulcer improvement: a pilot study"],"prefix":"10.1111","volume":"13","author":[{"given":"Joshua D","family":"Fox","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L","family":"Baquerizo\u2010Nole","sequence":"additional","affiliation":[{"name":"Department of Medicine Nassau University Medical Center Nassau NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian R","family":"Keegan","sequence":"additional","affiliation":[{"name":"Windsor Dermatology East Windsor NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flor","family":"Macquhae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Escandon","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliette","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S","family":"Kirsner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012207.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2014.903258"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0268355513476844"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00748.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.012"},{"key":"e_1_2_6_9_1","first-page":"703","article-title":"Influence of HLA\u2010DRB1 and TNF microsatellite polymorphisms on the expression of extraarticular manifestations in rheumatoid arthritis patients from northwest Spain","volume":"19","author":"Mattey DL","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700143"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2006.00233.x"},{"key":"e_1_2_6_12_1","unstructured":"Administration FaD. Highlights of prescribing information of Humira 2011. URLhttp:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/125057s0215lbl.pdf[accessed on 25 June 2015]"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00379-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.01.038"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12497","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T21:49:03Z","timestamp":1696196943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,24]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/iwj.12497"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12497","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,24]]},"assertion":[{"value":"2015-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}