{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:09:03Z","timestamp":1790356143144,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic venous insufficiency (<jats:styled-content style=\"fixed-case\">CVI<\/jats:styled-content>) is the most advanced form of chronic venous disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>), and is often associated with skin changes such as hyperpigmentation, eczema, lipodermatosclerosis and venous skin ulceration that cause discomfort, pain, sleep disturbances, absenteeism in the workplace, disability and deteriorated quality of life (<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>). The purpose of this study is to evaluate the prevalence of <jats:styled-content style=\"fixed-case\">CVI<\/jats:styled-content> and skin changes in patients who turn to Continuous Assistance Services due to the presence of disturbing symptoms of their condition.<\/jats:p><jats:p>Data were evaluated by consulting the medical records, during a 16\u2010month period, available with three Continuous Assistance Services of the Italian territory.<\/jats:p><jats:p>The overall population of the referring centres consisted of 1186 patients [739 females (62\u00b731%) and 447 males (37\u00b769%)]. Seventy\u2010nine patients (6\u00b766%) consulted the emergency unit for venous symptoms related to <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>. Patients with more severe disease (<jats:styled-content style=\"fixed-case\">CVI<\/jats:styled-content>, categories <jats:styled-content style=\"fixed-case\">C4\u2013C6<\/jats:styled-content>) represented the majority accounting for 60\u00b775%, while patients with moderate disease (<jats:styled-content style=\"fixed-case\">C3<\/jats:styled-content>) accounted for 35\u00b744% and patients with mild disease (<jats:styled-content style=\"fixed-case\">C1\u2013C2<\/jats:styled-content> stages) accounted for 3\u00b779%.<\/jats:p><jats:p>The main finding of this study is that despite <jats:styled-content style=\"fixed-case\">CVI<\/jats:styled-content> not being a disease that commonly requires medical emergency\/urgency intervention, patients with <jats:styled-content style=\"fixed-case\">CVI<\/jats:styled-content>, especially in advanced stage with skin changes, may turn to Continuous Assistance Service for treating bothersome symptoms related to their condition.<\/jats:p>","DOI":"10.1111\/iwj.12498","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T08:25:57Z","timestamp":1441700757000},"page":"967-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Symptoms in patients with skin changes due to chronic venous insufficiency often lead to emergency care service: an Italian observational study"],"prefix":"10.1111","volume":"13","author":[{"given":"Michele","family":"Ruggiero","sequence":"first","affiliation":[{"name":"Department of Surgery Annunziata Hospital of Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Grande","sequence":"additional","affiliation":[{"name":"Department of Primary Care Provincial Health Authority of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Naso","sequence":"additional","affiliation":[{"name":"Department of Primary Care Provincial Health Authority of Vibo Valentia  Vibo Valentia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Butrico","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Rubino","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2018Pugliese\u2010Ciaccio\u2019 Hospital  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girolamo Domenico","family":"Placida","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2018Pugliese\u2010Ciaccio\u2019 Hospital  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cannistr\u00e0","sequence":"additional","affiliation":[{"name":"Department of Surgery Annunziata Hospital of Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.11.036"},{"key":"e_1_2_5_3_1","unstructured":"SerraR GrandeR ButricoL FugettoF deFranciscisS. 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