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Patients who develop ulcers appear to have a more severe haemolysis\u2010associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. <jats:styled-content style=\"fixed-case\">SCLUs<\/jats:styled-content> are slow to heal and often recur, affecting both the emotional and physical well\u2010being of patients. Here we summarise what is known about the pathophysiology of <jats:styled-content style=\"fixed-case\">SCLUs<\/jats:styled-content>, describe available treatment options and propose a treatment algorithm.<\/jats:p>","DOI":"10.1111\/iwj.12522","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T04:06:58Z","timestamp":1446696418000},"page":"1315-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease"],"prefix":"10.1111","volume":"13","author":[{"given":"Igor A","family":"Altman","sequence":"first","affiliation":[{"name":"Department of Surgery, Section of Wound Healing and Tissue Repair University of Illinois Hospital and Health Sciences System  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond E","family":"Kleinfelder","sequence":"additional","affiliation":[{"name":"Traditional Rotating Internship, Genesys Regional Medical Center  Grand Blanc MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Quigley","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology University of Illinois Hospital and Health Sciences System  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Ennis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Wound Healing and Tissue Repair University of Illinois Hospital and Health Sciences System  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina P","family":"Minniti","sequence":"additional","affiliation":[{"name":"Department of Oncology, Division of Hematology, Sickle Cell Center Montefiore Medical Center  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2013.789968"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70404-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08323.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05025.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2012.751033"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.08.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(98)00196-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000419408.37323.0c"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199510000-00024"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21838"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.598"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0980667"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03833.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07115.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23571"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200410000-00010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(14)00019-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00282-996-0279-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-6-534"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(01)00336-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199703000-00024"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90049-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008394.pub3"},{"key":"e_1_2_7_25_1","first-page":"121","article-title":"A randomized controlled trial of solcoseryl and duoderm in chronic sickle\u2010cell ulcers","volume":"42","author":"La Grenade L","year":"1993","journal-title":"West Indian Med J"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1182\/blood.V84.6.1775.1775","article-title":"Accelerated healing of chronic sickle\u2010cell leg ulcers treated with RGD peptide matrix. 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