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Eight hundred and sixty diabetic patients were admitted to the diabetic wound centre of the Korea University Guro Hospital for foot ulcers between January 2010 and December 2013. Among them, 837 patients were successfully monitored until complete healing. Ulcers in 809 patients (96\u00b77%) healed without major amputation and those in 28 patients (3\u00b73%) healed with major amputation. Data of 88 potential risk factors including demographics, ulcer condition, vascularity, bioburden, neurology and serology were collected from patients in the two groups and compared. Among the 88 potential risk factors, statistically significant differences between the two groups were observed in 26 risk factors. In the univariate analysis, which was carried out for these 26 risk factors, statistically significant differences were observed in 22 risk factors. In a stepwise multiple logistic analysis, six of the 22 risk factors remained statistically significant. Multivariate\u2010adjusted odds ratios were 11\u00b7673 for ulcers penetrating into the bone, 8\u00b7683 for dialysis, 6\u00b7740 for gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) disorders, 6\u00b7158 for hind foot ulcers, 0\u00b7641 for haemoglobin levels and 1\u00b7007 for fasting blood sugar levels. The risk factors for major amputation in diabetic foot patients were bony invasions, dialysis,<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>disorders, hind foot locations, low levels of haemoglobin and elevated fasting blood sugar levels.<\/jats:p>","DOI":"10.1111\/iwj.12526","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T09:06:27Z","timestamp":1445245587000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Risk factors for major amputation in hospitalised diabetic foot patients"],"prefix":"10.1111","volume":"13","author":[{"given":"Sik","family":"Namgoong","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyoung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Kyu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Sang","family":"Dhong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo\u2010Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Korea University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00181-0"},{"key":"e_1_2_7_3_1","first-page":"519","article-title":"Nontraumatic lower extremity amputations in diabetic and non\u2010diabetic subjects in Madrid, Spain","volume":"23","author":"Calle\u2010Pascual AL","year":"1997","journal-title":"Diabetes Metab"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658010-00007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.4.395"},{"issue":"1","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1002\/dme.1996.13.s1.12","article-title":"The pathogenesis of diabetic foot problems: an overview","volume":"13","author":"Boulton AJ","year":"1996","journal-title":"Diabet Med"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.1885"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.2337\/diab.42.6.876","article-title":"Lower\u2010extremity amputation. 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