{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:57:32Z","timestamp":1787579852463,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Abstract<\/jats:title>\n \n Venous thromboembolism (\n VTE<\/jats:styled-content>\n ) is a common complication after surgical treatment of fractures, which is associated with significant morbidity and mortality. Identifying the risk factors for\n VTE<\/jats:styled-content>\n is important for preventive strategies to reduce the incidence of\n VTE<\/jats:styled-content>\n . Therefore, we conducted a meta\u2010analysis to evaluate the incidence of\n VTE<\/jats:styled-content>\n and the risk factors influencing the development of\n VTE<\/jats:styled-content>\n in patients who underwent surgery for fractures below the hip.\n PubMed<\/jats:styled-content>\n , Embase, Web of Science,\n SinoMed<\/jats:styled-content>\n (Chinese\n BioMedical<\/jats:styled-content>\n Literature Service System, China) and\n CNKI<\/jats:styled-content>\n (National Knowledge Infrastructure, China) databases were systematically searched to identify cohort or case\u2013control studies that investigated the incidence and risk factors for\n VTE<\/jats:styled-content>\n following surgical treatment of fractures below the hip.\n VTE<\/jats:styled-content>\n risk ratios (\n RR<\/jats:styled-content>\n s) were pooled by use of a fixed\u2010effect model or a random\u2010effect model, depending on the heterogeneity among the included studies. Heterogeneity between the studies was assessed by\n \n I<\/jats:italic>\n 2<\/jats:sup>\n <\/jats:styled-content>\n statistics. Twenty\u2010three studies with a total of 191 294 patients who met the inclusion criteria were included in this meta\u2010analysis. Our results demonstrated that age (\u226560 years) (\n RR<\/jats:styled-content>\n = 1\u00b785, 95% confidence interval\n (CI)<\/jats:styled-content>\n : 1\u00b734, 2\u00b755;\n P<\/jats:italic>\n = 0\u00b7000), previous\n VTE<\/jats:styled-content>\n (\n RR<\/jats:styled-content>\n = 5\u00b725, 95%\n CI<\/jats:styled-content>\n : 2\u00b777, 9\u00b796;\n P<\/jats:italic>\n = 0\u00b7000), heart failure (\n RR<\/jats:styled-content>\n = 1\u00b774, 95%\n CI<\/jats:styled-content>\n : 1\u00b734, 2\u00b727;\n P<\/jats:italic>\n = 0\u00b7000), current smoking status (\n RR<\/jats:styled-content>\n = 1\u00b723, 95%\n CI<\/jats:styled-content>\n : 1\u00b707, 1\u00b741;\n P<\/jats:italic>\n = 0\u00b7004), hypertension (\n RR<\/jats:styled-content>\n = 1\u00b762, 95%\n CI<\/jats:styled-content>\n : 1\u00b727, 2\u00b706;\n P<\/jats:italic>\n = 0\u00b7000), hyperlipidaemia (\n RR<\/jats:styled-content>\n = 2\u00b716, 95%\n CI<\/jats:styled-content>\n : 1\u00b779, 2\u00b762;\n P<\/jats:italic>\n = 0\u00b7000), diabetes mellitus (\n RR<\/jats:styled-content>\n = 1\u00b746, 95%\n CI<\/jats:styled-content>\n : 1\u00b727, 1\u00b768;\n P<\/jats:italic>\n = 0\u00b7000), obesity (\n RR<\/jats:styled-content>\n = 1\u00b758, 95%\n CI<\/jats:styled-content>\n : 1\u00b735,\u00b71\u00b785;\n P<\/jats:italic>\n = 0\u00b7000), multiple fractures (\n RR<\/jats:styled-content>\n = 2\u00b714, 95%\n CI<\/jats:styled-content>\n : 1\u00b700, 4\u00b760;\n P<\/jats:italic>\n = 0\u00b7050), varicose veins (\n RR<\/jats:styled-content>\n = 3\u00b707, 95%\n CI<\/jats:styled-content>\n : 1\u00b712, 8\u00b747;\n P<\/jats:italic>\n = 0\u00b7030), prolonged operation time (weighted mean differences (\n WMD<\/jats:styled-content>\n ) = 1\u00b722, 95%\n CI<\/jats:styled-content>\n : 0\u00b763, 1\u00b781;\n P<\/jats:italic>\n = 0\u00b7000) and prolonged bed rest time (\n WMD<\/jats:styled-content>\n = 3\u00b712, 95%\n CI<\/jats:styled-content>\n : 2\u00b796, 3\u00b729;\n P<\/jats:italic>\n = 0\u00b7000) were associated with an increased risk of developing\n VTE<\/jats:styled-content>\n . The other variables, including age (<60 years), previous smoking, immobility, pregnancy, cancer, open fractures and combination with trauma were not identified as significant risk factors for\n VTE<\/jats:styled-content>\n . Almost all the risk factors mentioned above are in line with the known risk factors for\n VTE<\/jats:styled-content>\n following surgery for fractures below the hip. Thus, surgeons should pay close attention to patients with these medical conditions in order to reduce the incidence of\n VTE<\/jats:styled-content>\n following surgical treatment of fractures below the hip.\n <\/jats:p>","DOI":"10.1111\/iwj.12533","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T23:44:46Z","timestamp":1456962286000},"page":"1359-1371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Incidence and risk factors for venous thromboembolism following surgical treatment of fractures below the hip: a meta\u2010analysis"],"prefix":"10.1111","volume":"13","author":[{"given":"Lei","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Orthopedic Traumatology The First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baochang","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Traumatology The First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiecheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Traumatology The First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Traumatology The First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199805)68:1<41::AID-JSO9>3.0.CO;2-L"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-199601000-00007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016470052943883"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.5_Supplement.561S"},{"key":"e_1_2_6_6_1","first-page":"S6","article-title":"Prevalence and economic burden of venous thromboembolism after total hip arthroplasty or total knee arthroplasty","volume":"17","author":"Baser O","year":"2011","journal-title":"Am J Manag Care"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1412S3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200103000-00004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1302\/0301-620X.85B5.14012","article-title":"Incidence and natural history of deep\u2010vein thrombosis after total hip arthroplasty. 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