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They act as secondary messengers to many immunocytes and non\u2010lymphoid cells, which are involved in the repair process, and appear to be important in coordinating the recruitment of lymphoid cells to the wound site and effective tissue repair.\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    also possess the ability to regulate the formation of blood vessels (angiogenesis) at the wound site and the optimal perfusion of blood into the wound\u2010healing area.\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    act in the host's defence through phagocytes that induce an\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    burst onto the pathogens present in wounds, leading to their destruction, and during this period, excess\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    leakage into the surrounding environment has further bacteriostatic effects. In light of these important roles of\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    in wound healing and the continued quest for therapeutic strategies to treat wounds in general and chronic wounds, such as diabetic foot ulcers, venous and arterial leg ulcers and pressure ulcers in particular, the manipulation of\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    represents a promising avenue for improving wound\u2010healing responses when they are stalled. This article presents a review of the evidence supporting the critical role of\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    in wound healing and infection control at the wound site, and some of the new emerging concepts associated with\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    modulation and its potential in improving wound healing are discussed.\n                  <\/jats:p>","DOI":"10.1111\/iwj.12557","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T03:04:41Z","timestamp":1450667081000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1313,"title":["Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS\u2010modulating technologies for augmentation of the healing 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