{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:43:24Z","timestamp":1785480204505,"version":"3.56.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skin grafting is one of the most common surgical procedures in the area of non\u2010healing wounds by which skin or a skin substitute is placed over a wound to replace and regenerate the damaged skin. Chronic leg ulcers are an important problem and a major source of expense for Western countries and for which many different forms of treatment have been used. Skin grafting is a method of treatment that decreases the area of chronic leg ulcers or heals them completely, thus improving a patient's quality of life. Skin grafting is an old technique, rediscovered during the first and second world wars as the main treatment for wound closure. Nowadays, skin grafting has a pivotal role in the context of modern wound healing and tissue regeneration. The aim of this review was to track and to analyse the specific outcomes this technique achieved, especially in the last decade, in relation to venous, arterial, diabetic, rheumatoid and traumatic leg ulcers. Our main findings indicate that autologous split\u2010thickness skin grafting still remains the gold standard in terms of safety and efficacy for chronic leg ulcers; skin grafting procedures have greater success rates in chronic venous leg ulcers compared to other types of chronic leg ulcers; skin tissue engineering, also supported by genetic manipulation, is quickly expanding and, in the near future, may provide even better outcomes in the area of treatments for long\u2010lasting chronic wounds.<\/jats:p>","DOI":"10.1111\/iwj.12575","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T16:34:35Z","timestamp":1457195675000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Skin grafting for the treatment of chronic leg ulcers \u2013 a systematic review in evidence\u2010based medicine"],"prefix":"10.1111","volume":"14","author":[{"given":"Raffaele","family":"Serra","sequence":"first","affiliation":[{"name":"Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Graecia of Catanzaro  Catanzaro Italy"},{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Rizzuto","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cVincenzo Tiberio\u201d University of Molise  Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Perri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Barbetta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo","family":"Caroleo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Hospital of Saint\u2010Flour  Saint\u2010Flour France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Amantea","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Sammarco","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"de Franciscis","sequence":"additional","affiliation":[{"name":"Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology University Magna Graecia of Catanzaro  Catanzaro Italy"},{"name":"Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70199-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.07.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yadr.2006.07.002"},{"key":"e_1_2_6_5_1","first-page":"51","article-title":"Greffes epidermiques","volume":"10","author":"Reverdin JL","year":"1869","journal-title":"Bull Soc Impe Chir Paris"},{"key":"e_1_2_6_6_1","first-page":"82","article-title":"The use and uses of large split skin grafts of intermediate thickness","volume":"49","author":"Blair V","year":"1929","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1993.tb00424.x"},{"key":"e_1_2_6_8_1","first-page":"9","article-title":"Epidemiology. Diagnosis and treatment of chronic leg ulcers: a systematic review","volume":"16","author":"Serra R","year":"2015","journal-title":"Acta Phlebol"},{"key":"e_1_2_6_9_1","first-page":"129","article-title":"Skin grafting and topical application of platelet gel in the treatment of vascular lower extremity ulcers","volume":"15","author":"Serra R","year":"2014","journal-title":"Acta Phlebol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.07.028"},{"key":"e_1_2_6_11_1","volume-title":"Elective incision and scar revision","author":"Borges AF","year":"1973"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1997.tb00666.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2228-x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1990.tb00020.x"},{"key":"e_1_2_6_15_1","first-page":"702A","article-title":"Successful engraftment of allogeneic keratinocytes in recessive dystrophic epidermolysis bullosa","volume":"35","author":"McGuire J","year":"1987","journal-title":"Clin Res"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(47)90360-7"},{"key":"e_1_2_6_17_1","first-page":"16","volume-title":"Michigan manual of plastic surgery","author":"Chang EY","year":"2004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(58)90975-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(02)00086-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199307000-00006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.3.344"},{"key":"e_1_2_6_22_1","first-page":"61","article-title":"Skin grafts","volume":"86","author":"Jo Leung J","year":"2009","journal-title":"UTMJ"},{"key":"e_1_2_6_23_1","first-page":"56349","article-title":"Skin graft","volume":"2012","author":"Shimizu R","year":"2012","journal-title":"Plast Surg Int"},{"key":"e_1_2_6_24_1","first-page":"213","article-title":"Wound bed preparation: the science behind the removal of barriers to healing","volume":"15","author":"Enoch S","year":"2003","journal-title":"Wounds"},{"issue":"7","key":"e_1_2_6_25_1","first-page":"23S","article-title":"Using wound debridement to help achieve the goals of care","volume":"41","author":"Fowler E","year":"1995","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_26_1","first-page":"14","article-title":"Preparing the wound bed: debridement, bacterial balance, and moisture balance","volume":"46","author":"Sibbald RG","year":"2000","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70164-B"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12500"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199706000-00002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.12.017"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000009"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.8.930"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1062-0303(99)90002-X"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.04.008"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-4-200302180-00012"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0802444"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00174.x"},{"key":"e_1_2_6_38_1","first-page":"222","article-title":"Use of split\u2010skin grafting in the treatment of chronic leg ulcers","volume":"77","author":"Wood MK","year":"1995","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_6_39_1","first-page":"CD001737","article-title":"Skin grafting for venous leg ulcers","volume":"1","author":"Jones JE","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06674.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1317"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05222.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7537.347"},{"key":"e_1_2_6_44_1","first-page":"511","article-title":"The diabetic foot: epidemiology","volume":"22","author":"Mancini L","year":"1997","journal-title":"Rays"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.12.046"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aorn.2008.02.002"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000288217.83128.f3"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(87)80006-7"},{"key":"e_1_2_6_49_1","first-page":"507","article-title":"The frequency of leg ulceration in rheumatoid arthritis: a survey","volume":"10","author":"Thurtle OA","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.7.816"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken129"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198269010-00001"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658010-00007"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2002.3827"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2012.12.002"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.08.001"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12035"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12181"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12464"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12085"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.02.049"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.09.009"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.04.018"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.295"},{"key":"e_1_2_6_65_1","first-page":"139","article-title":"Use of a novel hydrosurgery device in surgical debridement of difficult to heal wounds","volume":"20","author":"Pascone M","year":"2008","journal-title":"Wounds"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12575","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:15:42Z","timestamp":1696169742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,4]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/iwj.12575"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12575","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,4]]},"assertion":[{"value":"2015-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}