{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:35:58Z","timestamp":1787236558913,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:00:00Z","timestamp":1460419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001765","name":"Musculoskeletal Transplant Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>\n \n Acellular dermal matrices can successfully heal wounds. This study's goal was to compare clinical outcomes of a novel, open\u2010structure human reticular acellular dermis matrix (\n HR\u2010ADM<\/jats:styled-content>\n ) to facilitate wound closure in non\u2010healing diabetic foot ulcers (\n DFUs<\/jats:styled-content>\n ) versus\n DFUs<\/jats:styled-content>\n treated with standard of care (\n SOC<\/jats:styled-content>\n ). Following a 2\u2010week screening period in which\n DFUs<\/jats:styled-content>\n were treated with offloading and moist wound care, patients were randomised to either\n SOC<\/jats:styled-content>\n alone or\n HR\u2010ADM<\/jats:styled-content>\n plus\n SOC<\/jats:styled-content>\n applied weekly for up to 12 weeks. At 6 weeks, the primary outcome time, 65% of the\n HR\u2010ADM<\/jats:styled-content>\n \u2010treated\n DFUs<\/jats:styled-content>\n healed (13\/20) compared with 5% (1\/20) of\n DFUs<\/jats:styled-content>\n that received\n SOC<\/jats:styled-content>\n alone. At 12 weeks, the proportions of\n DFUs<\/jats:styled-content>\n healed were 80% and 20%, respectively. Mean time to heal within 12 weeks was 40 days for the\n HR\u2010ADM<\/jats:styled-content>\n group compared with 77 days for the\n SOC<\/jats:styled-content>\n group. There was no incidence of increased adverse or serious adverse events between groups or any adverse events related to the graft. Mean and median graft costs to closure per healed wound in the\n HR\u2010ADM<\/jats:styled-content>\n group were $1475 and $963, respectively. Weekly application of\n HR\u2010ADM<\/jats:styled-content>\n is an effective intervention for promoting closure of non\u2010healing\n DFUs<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/iwj.12600","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T23:11:38Z","timestamp":1460502698000},"page":"307-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["A prospective, randomised, controlled, multicentre clinical trial examining healing rates, safety and cost to closure of an acellular reticular allogenic human dermis versus standard of care in the treatment of chronic diabetic foot ulcers"],"prefix":"10.1111","volume":"14","author":[{"given":"Charles M","family":"Zelen","sequence":"first","affiliation":[{"name":"Department of Medical Education Professional Education and Research Institute Roanoke VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P","family":"Orgill","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Serena","sequence":"additional","affiliation":[{"name":"Serena Group Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions Inc. Cody WY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A","family":"DiDomenico","sequence":"additional","affiliation":[{"name":"Lower Extremity Institute for Research and Therapy Youngstown OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Keller","sequence":"additional","affiliation":[{"name":"Shenandoah Lower Extremity Research Troutville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod","family":"Kaufman","sequence":"additional","affiliation":[{"name":"General Surgery Premier Surgical Brick NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W","family":"Li","sequence":"additional","affiliation":[{"name":"The Angiogenesis Foundation Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10029"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10030"},{"key":"e_1_2_6_4_1","series-title":"Data Points Publication Series [Internet]","volume-title":"Incidence of diabetic foot ulcer and lower extremity amputation among medicare beneficiaries, 2006 to 2008: Data Points #2","author":"Margolis DJ","year":"2011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.5.692"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1696"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1879"},{"key":"e_1_2_6_8_1","first-page":"44","article-title":"A post\u2010hoc analysis of reduction in diabetic foot ulcer size at 4 weeks as a predictor of healing by 12 weeks","volume":"56","author":"Snyder RJ","year":"2010","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1300"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1323"},{"key":"e_1_2_6_11_1","volume-title":"An expert working group review. International consensus: acellular matrices for the treatment of wounds","author":"Harding K","year":"2010"},{"key":"e_1_2_6_12_1","first-page":"3","volume-title":"Comprehensive wound management","author":"Irion G","year":"2010"},{"key":"e_1_2_6_13_1","first-page":"344","volume-title":"Wound healing: biochemical and clinical aspects","author":"Mast BA","year":"1992"},{"key":"e_1_2_6_14_1","first-page":"16","article-title":"Regenerative healing in fetal skin: a review of the literature","volume":"53","author":"Wilgus TA","year":"2007","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000258829.07399.f0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/698034"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91838-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(00)00096-6"},{"key":"e_1_2_6_19_1","first-page":"40","article-title":"A cross\u2010sectional validation study of using NERDS and STONEES to assess bacterial burden","volume":"55","author":"Woo KY","year":"2009","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_20_1","first-page":"267","article-title":"Wounds measured from digital photographs using photodigital planimetry software: validation and rater reliability","volume":"23","author":"Wendelken ME","year":"2011","journal-title":"Wounds"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1999.00201.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.290"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1701"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00585.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12395"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12566"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.08.003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201403039"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12185"},{"issue":"1","key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"s145","DOI":"10.3928\/0147-7447-20040102-14","article-title":"Effective management of major lower extremity wounds using an acellular regenerative tissue matrix: a pilot study","volume":"27","author":"Brigido SA","year":"2004","journal-title":"Orthopedics"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2006.00209.x"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12600","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:43:54Z","timestamp":1696167834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,12]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/iwj.12600"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12600","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,12]]},"assertion":[{"value":"2016-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}