{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:23:30Z","timestamp":1768296210490,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T00:00:00Z","timestamp":1470700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this article was to assess the ability to predict reulceration in people with diabetes and a history of minor amputation according to the formula proposed by Miller <jats:italic>et al.<\/jats:italic> A retrospective study was performed on 156 consecutive records of patients with a recent history of simple or multiple forefoot amputation. The sample was divided according to Miller's formula into patients at low risk of reulceration and those at high risk; those were further divided into two subgroups according to whether or not the first segment of the forefoot had been amputated. Forty\u2010eight (47\u00b71%) individuals suffered forefoot reulceration, showing a median reulceration\u2010free survival time of 8 months [interquartile range (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) 3\u00b76\u201314\u00b78]. Nephropathy (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) and Miller's formula (<jats:italic>P<\/jats:italic>\u2009=\u20090.028) were risk factors for reulceration\u2010free survival time in the univariate analysis. The pattern relating to the first segment amputated [hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 2\u00b7853; <jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7004; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1\u00b7391\u20135\u00b7849] and nephropathy (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2\u00b7468; <jats:italic>P<\/jats:italic>\u2009=\u20090.004; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.328\u20134.587) showed a significant hazard ratio in the multivariate Cox model. Participants with first segment amputation and one other amputation showed an association with the probability of reulceration in comparison with any other specific type of minor amputation.<\/jats:p>","DOI":"10.1111\/iwj.12639","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T08:00:53Z","timestamp":1470729653000},"page":"523-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Validation of an algorithm to predict reulceration in amputation patients with diabetes"],"prefix":"10.1111","volume":"14","author":[{"given":"Ra\u00fal J","family":"Molines\u2010Barroso","sequence":"first","affiliation":[{"name":"Unidad de Pie Diab\u00e9tico, Facultad de Medicina, Universidad Complutense de Madrid Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L","family":"L\u00e1zaro\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unidad de Pie Diab\u00e9tico, Facultad de Medicina, Universidad Complutense de Madrid Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J","family":"\u00c1lvaro\u2010Afonso","sequence":"additional","affiliation":[{"name":"Unidad de Pie Diab\u00e9tico, Facultad de Medicina, Universidad Complutense de Madrid Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Sanz\u2010Corbal\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Pie Diab\u00e9tico, Facultad de Medicina, Universidad Complutense de Madrid Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L","family":"Garc\u00eda\u2010Klepzig","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Interna, Hospital Cl\u00ednico San Carlos Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Arag\u00f3n\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Pie Diab\u00e9tico, Hospital La Paloma Las Palmas de Gran Canaria  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0491-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13169-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1089-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12202"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.2.165"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12249"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-80-3-120"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.03.06.dc05-1992"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1598"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wndm.2014.02.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis346"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.09.024"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2003.00933.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9021"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2252"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2253"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.464"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v3i0.12169"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1067-2516(97)80116-0"},{"key":"e_1_2_6_22_1","first-page":"192","article-title":"Amputation of the great toe. 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