{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:24:55Z","timestamp":1787793895822,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>\n \n Squamous cell carcinoma (\n SCC<\/jats:styled-content>\n ) arising from chronic hidradenitis suppurativa (\n HS<\/jats:styled-content>\n ) is rare; however, the morbidity associated with this presentation is high and management has not been standardised or optimised. We present a case of\n HS<\/jats:styled-content>\n of the perineum and buttocks complicated by\n SCC<\/jats:styled-content>\n , requiring multiple extensive surgical resections. Adjuvant radiotherapy was withheld initially because of concern for poor healing of the surgical wound but was eventually initiated after a second recurrence was identified. The patient ultimately expired 4 years after the initial diagnosis of\n SCC<\/jats:styled-content>\n . We also review 80 cases of\n SCC<\/jats:styled-content>\n complicating\n HS<\/jats:styled-content>\n found in the English literature. Case reports and mechanistic studies suggest the possibility that human papilloma virus and smoking may be risk factors associated with\n SCC<\/jats:styled-content>\n in\n HS<\/jats:styled-content>\n . Despite the majority of\n SCC<\/jats:styled-content>\n cases being well\u2010differentiated tumours in\n HS<\/jats:styled-content>\n , the highly aggressive nature of\n SCC<\/jats:styled-content>\n in\n HS<\/jats:styled-content>\n and its high likelihood for rapid progression, recurrence, metastasis and high mortality suggests the need to advocate for aggressive treatment. We recommend an aggressive approach to management at the time of\n SCC<\/jats:styled-content>\n diagnosis in\n HS<\/jats:styled-content>\n , which includes appropriate imaging to establish the extent of the tumour, large and deep surgical excision, sentinel lymph node evaluation, consultation with radiation oncology for potential adjuvant radiation therapy and close surveillance.\n <\/jats:p>","DOI":"10.1111\/iwj.12671","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T02:03:00Z","timestamp":1475114580000},"page":"435-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Squamous cell carcinoma complicating a chronic lesion of hidradenitis suppurativa: a case report and review of the literature"],"prefix":"10.1111","volume":"14","author":[{"given":"Natanel","family":"Jourabchi","sequence":"first","affiliation":[{"name":"Department of Dermatology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander H","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Cimino\u2010Mathews","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginette A","family":"Okoye","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480807401209"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000269836"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00346224"},{"key":"e_1_2_5_5_1","first-page":"1","article-title":"Squamous cell carcinoma in the setting of chronic hidradenitis suppurativa: report of a patient and update of the literature","volume":"21","author":"Pena ZG","year":"2015","journal-title":"Dermatol Online 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