{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:45:29Z","timestamp":1787165129441,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,12]]},"abstract":"\n Mutilated hand injuries are a profound challenge to the plastic surgeon, and such injuries often lead to limb loss and severe functional impairment. Hyperbaric oxygen therapy (\n HBOT<\/jats:styled-content>\n ) appears to counteract tissue hypoxia and stimulate acute wound healing. This study was performed to evaluate the efficacy of\n HBOT<\/jats:styled-content>\n as an adjunctive therapy in patients with a mutilated hand injury. Between January 2006 and December 2014, 45 patients with a mutilated hand injury were enrolled. After reconstruction or revascularisation, patients underwent 120 minutes of\n HBOT<\/jats:styled-content>\n with oxygen at 2\u00b75 atmospheres absolute while breathing 100% oxygen. Outcomes such as amputee survival and surgery\u2010related complications were recorded. The patients were 38 men and 7 women with average age of 37\u00b72 years (range 18\u201362). The mean defect area was 131\u00b75 cm\n 2<\/jats:sup>\n (range 40\u2013300). Most patients experienced a pure crush injury (53%). The average number of operations from the initial debridement to the first reconstruction was 3\u00b78 (range 1\u20136). A total of 33 patients (73%) underwent replantation during the initial reconstruction. For flap coverage, most patients received a free flap using an anterolateral thigh flap (18 patients) or local flap using an abdomen\/groin flap (nine patients). The average time from the first reconstruction or revascularisation to the first\n HBOT<\/jats:styled-content>\n was 6\u00b75 hours (range 2\u201312). The average number of\n HBOT<\/jats:styled-content>\n sessions was 9\u00b71 (range 6\u201314 sessions). The survival rate of the replanted fingers was 81%, and the survival rate of the palms was 100%. Most complications in the initial reconstruction involved partial loss of an avulsed flap, and most complications in the chronic stage (\u22653 months) involved scar contracture. When combined with delicate microsurgery, early intervention using adjunctive\n HBOT<\/jats:styled-content>\n was effective in preserving partially viable tissue and restoring hand function in patients with a mutilated hand injury.\n <\/jats:p>","DOI":"10.1111\/iwj.12730","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T23:52:49Z","timestamp":1488412369000},"page":"929-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Is hyperbaric oxygen therapy indispensable for saving mutilated hand injuries?"],"prefix":"10.1111","volume":"14","author":[{"given":"I\u2010Han","family":"Chiang","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Sheng","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Hyperbaric Oxygen Therapy Center, Shuang\u2010Ho Hospital Taipei Taiwan Republic of China"},{"name":"Department of Surgery, School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan Republic of 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