{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:41:17Z","timestamp":1790041277032,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,12]]},"abstract":"ABSTRACT<\/jats:styled-content><\/jats:title>Calciphylaxis (CPX<\/jats:styled-content>) is a rare calcifying thrombotic vasculopathy responsible for painful necrotic ulcers, with a high mortality rate, and its management is often difficult. Recently, intravenous infusions of sodium thiosulfate (STS<\/jats:styled-content>) have shown efficacy. The aim of this study was to assess the efficacy of intralesional STS<\/jats:styled-content> (IL STS<\/jats:styled-content>) in four patients. Our aim was to assess the efficacy of IL STS<\/jats:styled-content> in a prospective mono\u2010centric open study that included four patients with a biopsy\u2010proven cutaneous CPX<\/jats:styled-content>. Four women (55\u201384 years old, mean age: 71\u00b72 years) with a uremic (n<\/jats:italic> = 1) or non\u2010uremic CPX<\/jats:styled-content> (n<\/jats:italic> = 3) and primary hyperparathyroidism induced by teriparatide or after the initiation of oral anti\u2010vitamin K were treated by IL STS<\/jats:styled-content> (250 mg\/ml<\/jats:styled-content>). The injections were performed around the ulcers, on the active borders, once or twice a week and then at 1\u20102 weeks intervals. The injected quantity varied from 1\u00b75 to 15 ml<\/jats:styled-content>. Pain usually improved after two series of injections. Clinical response was visible after 2 weeks. Three patients (75%) healed completely or almost completely. A failure was observed in the last patient who also had lower limb arteriopathy. The main side effect was the pain during injections. IL STS<\/jats:styled-content> is an interesting alternative therapeutic option in the management of CPX<\/jats:styled-content> necrotic ulcers with limited side effects. Larger studies are warranted to precisely define its place, its administration procedure and the patients who could benefit from it.<\/jats:p>","DOI":"10.1111\/iwj.12738","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T16:42:32Z","timestamp":1490200952000},"page":"955-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Benefits of intralesional injections of sodium thiosulfate in the treatment of calciphylaxis"],"prefix":"10.1111","volume":"14","author":[{"given":"Kirsi","family":"Isoherranen","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kluger","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2015.06.009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2010.00738.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.99"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.4565"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2015.10.013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.013"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2580-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.065"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2005.11.001"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12139"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2206"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:21:28Z","timestamp":1696504888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/iwj.12738"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12738","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,21]]},"assertion":[{"value":"2016-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}