{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:04:45Z","timestamp":1791471885330,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this prospective, non\u2010randomised study was to evaluate the performance of an antibacterial foam dressing containing methylene blue and gentian violet (Hydrofera Blue Classic dressing<jats:sup>\u00ae<\/jats:sup>) for the management of chronic wounds with local infection. Patients in this study were \u226518 years of age (<jats:italic>n<\/jats:italic> = 29), and each had at least one chronic wound \u22651 cm<jats:sup>2<\/jats:sup> in size that showed signs of localised infection or critical colonisation but with good potential for healing based on clinical assessment. To all of these wounds, the dressing was applied and changed three times per week over the 4\u2010week study period. The primary endpoints of the study were: (i) changes in wound surface area measurement, (ii) changes in Pressure Ulcer Scale for Healing (<jats:styled-content style=\"fixed-case\">PUSH<\/jats:styled-content>) scores, (iii) changes in percent surface area of devitalised tissue (i.e., yellow slough or other necrotic tissue) and (iv) changes in clinical signs associated with localised wound infection\/critical colonisation. Participants were evaluated at presentation (week 0 = baseline), week 2 and at week 4 (end of the study). The 29 patients completed the study, and at week 4, the following wound improvements were observed: (i) baseline mean wound surface area was significantly reduced by 42\u00b75%, from 21\u00b74 to 12\u00b73 cm<jats:sup>2<\/jats:sup> at week 4 (<jats:italic>P<\/jats:italic> = 0\u00b7005); (ii) baseline mean <jats:styled-content style=\"fixed-case\">PUSH<\/jats:styled-content> score decreased significantly from 13\u00b73 to 10\u00b77 at week 4 (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001); (iii) baseline mean wound coverage by devitalised tissue (%) was significantly reduced, from 52\u00b76 % to 11\u00b74% at week 4 (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001) and (iv) the mean <jats:styled-content style=\"fixed-case\">UPPER<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LOWER<\/jats:styled-content> wound infection scores were reduced from 3\u00b76 at baseline to 0\u00b79 at week 4 (75%; <jats:italic>P<\/jats:italic> &lt; 0.001). These results indicate that the Hydrofera Blue Classic dressing was effective at managing these chronic wounds and helped them progress onto a healing trajectory.<\/jats:p>","DOI":"10.1111\/iwj.12753","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T09:02:43Z","timestamp":1494925363000},"page":"1029-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A prospective evaluation of methylene blue and gentian violet dressing for management of chronic wounds with local infection"],"prefix":"10.1111","volume":"14","author":[{"given":"Kevin Y","family":"Woo","sequence":"first","affiliation":[{"name":"School of Nursing, Faculty of Health Sciences Queen's University  Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolene","family":"Heil","sequence":"additional","affiliation":[{"name":"School of Nursing, Faculty of Health Sciences Queen's University  Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"e_1_2_7_5_1","unstructured":"Canadian Agency for Drugs and Technologies in Health. Optimal care of chronic non\u2010healing lower extremity wounds: a review of clinical evidence and guidelines. Ottawa ON Canada 2013(Canadian Institute for Health Information. Compromised wounds in Canada. Ottawa: CIHI; 2013.) 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URLhttp:\/\/www.worldwidewounds.com\/2004\/february\/Cooper\/Topical\u2010Antimicrobial\u2010Agents[accessed on 21 June 2016]."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.00991.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.10.1241"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.07.050"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2011.9.6851"},{"key":"e_1_2_7_16_1","volume-title":"Position Document: Management of Wound Infection","author":"European Wound Management Association (EWMA)","year":"2006"},{"key":"e_1_2_7_17_1","first-page":"45","article-title":"Topical antimicrobial toolkit for wound infection","volume":"25","author":"Woo KY","year":"2014","journal-title":"Surg Technol Int"},{"key":"e_1_2_7_18_1","unstructured":"United States Food and Drug Administration. Premarked Notification 510(K) Hydrofera LLC. January 4 2014. 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