{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:41:07Z","timestamp":1791636067292,"version":"4.3.4"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T00:00:00Z","timestamp":1500768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several anaesthetic drugs have demonstrated antibacterial properties in vitro. Anaesthetics can primarily affect the cell wall of both susceptible and multi\u2010resistant bacteria. They may also have a synergistic effect with conventional antibiotics through an unknown mechanism. We present three cases of a chronic venous ulcer infected by multi\u2010resistant bacteria refractory to conventional systemic antibiotics, including <jats:italic>Pseudomonas aeruginosa<\/jats:italic> and methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA). Treatment with topical sevoflurane was performed for 1 month without systemic antibiotics. Patients with an MRSA infection showed progressive improvement with negative culture at the end of the treatment. Multi\u2010drug\u2010resistant <jats:italic>P. aeruginosa<\/jats:italic> infection persisted at the end of treatment with positive culture. The local adverse events were mild and transient, including heat, pruritus and erythema. Topical sevoflurane may have an antibacterial effect on sensitive and multi\u2010resistant strains. It can allow more complete surgical cleaning, leaving a cleaner wound with less fibrin and necrotic tissue. This decreases the bacterial colonisation and therefore the infectious risk, the bad smell and the exudation. The simultaneous use of conventional antibiotics and topical sevoflurane can have a synergistic antimicrobial effect.<\/jats:p>","DOI":"10.1111\/iwj.12794","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T04:52:35Z","timestamp":1500871955000},"page":"1388-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Topical sevoflurane for chronic venous ulcers infected by multi\u2010drug\u2010resistant organisms"],"prefix":"10.1111","volume":"14","author":[{"given":"Adri\u00e1n","family":"Imbern\u00f3n\u2010Moya","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Severo Ochoa  Legan\u00e9s Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Ortiz\u2010de Frutos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Doce de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Sanjuan\u2010Alvarez","sequence":"additional","affiliation":[{"name":"Department of Anestesiology Hospital Severo Ochoa  Legan\u00e9s Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Portero\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Merinero\u2010Palomares","sequence":"additional","affiliation":[{"name":"Department of Crystallography and Mineralogy Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Hospital Severo Ochoa  Legan\u00e9s Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-199907000-00001"},{"key":"e_1_2_4_3_1","first-page":"120","article-title":"Actividad bactericida del sevoflurano frente a Staphylococcus aureus, Pseudomonas aeruginosa y Escherichia coli","volume":"27","author":"Mart\u00ednez M","year":"2009","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"e_1_2_4_4_1","first-page":"84","article-title":"Antibacterial effect of sevoflurane and isoflurane","volume":"30","author":"Mart\u00ednez\u2010Serrano M","year":"2017","journal-title":"Rev Esp Quimioter"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.02.079"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.079"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12474"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiwj.12794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.12794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:22:23Z","timestamp":1696504943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.12794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,23]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/iwj.12794"],"URL":"https:\/\/doi.org\/10.1111\/iwj.12794","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,23]]},"assertion":[{"value":"2017-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}