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The questionnaires were evaluated in a randomly assigned order in a longitudinal observational study of leg ulcer patients. Psychometric properties (internal consistency, responsiveness and construct validity) were analysed. Patient acceptance was recorded. Analysis of<jats:italic>n<\/jats:italic>= 154 patients revealed good internal consistency (Cronbach's alpha \u2265 0\u00b785) for all instruments. There were minor floor effects in all questionnaires (&lt;1%) and some ceiling effects in the<jats:styled-content style=\"fixed-case\">CWIS<\/jats:styled-content>. Construct validity was satisfactory, for example, correlation with<jats:styled-content style=\"fixed-case\">EuroQoL\u20105D<\/jats:styled-content>was<jats:italic>r<\/jats:italic>= 0\u00b770 in the<jats:styled-content style=\"fixed-case\">FLQA<\/jats:styled-content>\u2010w,<jats:italic>r<\/jats:italic>= 0\u00b747\/0\u00b767\/0\u00b768 in the<jats:styled-content style=\"fixed-case\">CWIS<\/jats:styled-content>dimensions and<jats:italic>r<\/jats:italic>= 0\u00b760 in the<jats:styled-content style=\"fixed-case\">WWS<\/jats:styled-content>. The proportion of missing values was higher in the<jats:styled-content style=\"fixed-case\">CWIS<\/jats:styled-content>, and overall patient acceptance was highest in the<jats:styled-content style=\"fixed-case\">FLQA<\/jats:styled-content>\u2010w for wounds (54% best preferences) and lowest in the<jats:styled-content style=\"fixed-case\">WWS<\/jats:styled-content>(14%). In conclusion, the<jats:styled-content style=\"fixed-case\">FLQA<\/jats:styled-content>\u2010w, the<jats:styled-content style=\"fixed-case\">CWIS<\/jats:styled-content>and the<jats:styled-content style=\"fixed-case\">WWS<\/jats:styled-content>are reliable, sensitive and valid instruments for the assessment of<jats:styled-content style=\"fixed-case\">HRQoL<\/jats:styled-content>in leg ulcers. However, they show differences in clinical feasibility and patient acceptance.<\/jats:p>","DOI":"10.1111\/iwj.12803","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T08:02:47Z","timestamp":1504684967000},"page":"1299-1304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Quality\u2010of\u2010life evaluation in chronic wounds: comparative analysis of three disease\u2010specific questionnaires"],"prefix":"10.1111","volume":"14","author":[{"given":"Matthias","family":"Augustin","sequence":"first","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Baade","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University 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