{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:39:16Z","timestamp":1780385956885,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study assesses the efficacy and safety of topical sevoflurane in chronic venous ulcers and its impact on analgesia and healing.<\/jats:p><jats:p>This retrospective study included 30 patients older than 65 years with painful refractory chronic venous ulcers. Patients were treated with topical sevoflurane prior to the usual ulcer cleaning every 2 days for a period of 1 month. Treatment was initiated with a saline solution, followed by direct irrigation of 1 ml of liquid sevoflurane over the wound size, which was measured as cm<jats:sup>2<\/jats:sup>.<\/jats:p><jats:p>Sevoflurane had a fast, intense and long\u2010lasting analgesic effect. Latency time ranged from 2 to 7 minutes (3\u00b79 \u00b1 1\u00b75 minutes), and duration varied from 8 to 18 hours (12 \u00b1 2\u00b79). The mean ulcer size was 8\u00b74 \u00b1 9\u00b77 cm<jats:sup>2<\/jats:sup>. There was a progressive decrease in size in all patients, with a mean size of 4\u00b72 \u00b1 5\u00b74 cm<jats:sup>2<\/jats:sup> at the end of the study. There were no adverse systemic effects. Local adverse effects were mild and transient, including pruritus, erythema and heat.<\/jats:p><jats:p>Topical sevoflurane is a new, efficient and safe therapeutic alternative in painful chronic venous ulcers, refractory to usual analgesic treatment. It can improve the ulcer\u2010healing process that shortens the cicatrisation period.<\/jats:p>","DOI":"10.1111\/iwj.12806","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T02:42:40Z","timestamp":1503024160000},"page":"1323-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Healing of chronic venous ulcer with topical sevoflurane"],"prefix":"10.1111","volume":"14","author":[{"given":"Adrian","family":"Imbernon\u2010Moya","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Severo Ochoa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Ortiz\u2010de Frutos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Doce de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Sanjuan\u2010Alvarez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital Severo Ochoa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Portero\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Merinero\u2010Palomares","sequence":"additional","affiliation":[{"name":"Department of Crystallography and Mineralogy Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Hospital Severo Ochoa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111633"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2015.01.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04654.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142687"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.11.069"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107496"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.16.2192"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2003.12.9.26532"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2007.16.8.27856"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.079"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.07082_supp.x"},{"key":"e_1_2_6_13_1","first-page":"10","article-title":"Meeting the challenges of wound\u2010associated pain: anticipatory pain, anxiety, stress, and wound healing","volume":"54","author":"Woo KY","year":"2008","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.2.58"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936010-00002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2013.02.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-0037-1621757","article-title":"Analgesic effect of topical sevoflurane on venous ulcer intractable pain","volume":"40","author":"Ger\u00f3nimo\u2010Pardo M","year":"2011","journal-title":"Phlebologie"},{"key":"e_1_2_6_18_1","first-page":"46","article-title":"Sevoflurano como anest\u00e9sico local en herida isqu\u00e9mica de paciente cardi\u00f3pata con insuficiencia respiratoria secundaria a morfina","volume":"6","author":"Martinez Monsalve A","year":"2011","journal-title":"Heridas y cicatrizaci\u00f3n"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.079"},{"key":"e_1_2_6_20_1","first-page":"181","article-title":"Usos alternativos del sevoflurano. 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