{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:17:03Z","timestamp":1787620623242,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Health Commonwealth and Victorian State Governments"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this arm of the study was to investigate the impact of medication on healing times of the various wound types, including acute wounds and leg ulcers. A prospective longitudinal study design was used, with de\u2010identified data collected using an electronic mobile wound care database system. Three main categories of data were collected, including patients' demographics, wounds types and treatment characteristics. For acute wounds, there was a total of 1732 patients with 2089 acute wounds. The average healing time was about 35 days. The only significant association was with chemotherapy, which increased healing time by 21 days (<jats:italic>P<\/jats:italic> = 0\u00b7048). There were non\u2010significant trends towards reduced healing times with antibiotics (0\u00b75 days; <jats:italic>P<\/jats:italic> = 0\u00b7853), anticoagulants (1\u00b77 days, <jats:italic>P<\/jats:italic> = 0\u00b7673) and corticosteroids (4\u00b798 days, <jats:italic>P<\/jats:italic> = 0\u00b7303). Non\u2010steroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content>) were associated with a non\u2010significant increase in healing time (2\u00b717 days, <jats:italic>P<\/jats:italic> = 0\u00b7707). For leg ulcers, there was a total of 264 patients with 370 leg ulcers. We only examined the impact of antibiotics, anticoagulants, corticosteroids and <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content> on healing times as they had an adequate number of wounds to analyse. The average healing times of leg ulcers were found to be 73 days. None of the classes of medications had any significant impact on healing time. Both anticoagulants and <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content> increased healing time by (22\u00b75 days, <jats:italic>P<\/jats:italic> = 0\u00b708) and (12\u00b75 days, <jats:italic>P<\/jats:italic> = 0\u00b703), respectively. On the other hand, antibiotics and corticosteroids decreased healing times non\u2010significantly by (9\u00b71 days, <jats:italic>P<\/jats:italic> = 0\u00b733) and (21\u00b76 days, <jats:italic>P<\/jats:italic> = 0\u00b784), respectively.<\/jats:p>","DOI":"10.1111\/iwj.12809","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T08:52:40Z","timestamp":1506329560000},"page":"1340-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Medications affecting healing: an evidence\u2010based analysis"],"prefix":"10.1111","volume":"14","author":[{"given":"Hanan","family":"Khalil","sequence":"first","affiliation":[{"name":"School of Rural Health, Faculty of Medicine, Nursing and Health Sciences Monash University  Moe VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Cullen","sequence":"additional","affiliation":[{"name":"Latrobe Community Health Centre  Morwell VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Chambers","sequence":"additional","affiliation":[{"name":"School of Rural Health, Faculty of Medicine, Nursing and Health Sciences Monash University  Moe VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McGrail","sequence":"additional","affiliation":[{"name":"School of Rural Health, Faculty of Medicine, Nursing and Health Sciences Monash University  Moe VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Global Industry Analysts. 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