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It can maintain a physiologically moist microenvironment, which minimises bacterial infection and facilitates wound healing at a wound site. Patients with burn injuries suffer from pain and an inflammatory response. In this study, we evaluated the\n                    <jats:styled-content style=\"fixed-case\">CAPS<\/jats:styled-content>\n                    dressing and traditional dressing containing carboxymethyl cellulose (\n                    <jats:styled-content style=\"fixed-case\">CMC<\/jats:styled-content>\n                    ) for wound healing and scar tissue formation in a burn model of rat and swine. In our pilot study of a burn rat model to evaluate inflammatory response and wound healing, we found that the monocyte chemoattractant protein (\n                    <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\n                    )\u20101 and transforming growth factor (\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    )\u2010\u03b2 were up\u2010regulated in the\n                    <jats:styled-content style=\"fixed-case\">CAPS<\/jats:styled-content>\n                    treatment group. Next, the burn swine models tested positive for\n                    <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\n                    \u20101 in a Gram\u2010positive bacterial infection, and there was overproduction of\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b2 during the burn wound healing process. Rats were monitored daily for 1 week for cytokine assay and sacrificed on day 28 post\u2010burn injury. The swine were monitored over 6 weeks. We further examined the pain and related factors and inflammatory cytokine expression in a rodent burns model monitored everyday for 7 days post\u2010burn. Our results revealed that the efficacy of the dressing containing\n                    <jats:styled-content style=\"fixed-case\">CAPS<\/jats:styled-content>\n                    for wound repair post\u2010burn was better than the\n                    <jats:styled-content style=\"fixed-case\">CMC<\/jats:styled-content>\n                    dressing with respect to natural wound healing and scar formation. The polysaccharide\u2010enriched dressing exerted an antimicrobial effect on burn wounds, regulated the inflammatory response and stimulated anti\u2010inflammatory cytokine release. However, one pain assessment method showed no significant difference in the reduction in levels of adenosine triphosphate in serum of rats after wound dressing in either the\n                    <jats:styled-content style=\"fixed-case\">CAPS<\/jats:styled-content>\n                    or\n                    <jats:styled-content style=\"fixed-case\">CMC<\/jats:styled-content>\n                    group. In conclusion, a polysaccharide\u2010enriched dressing outperformed a traditional dressing in reducing wound size, minimising hypertrophic scar formation, regulating cytokines and maximising antimicrobial effects.\n                  <\/jats:p>","DOI":"10.1111\/iwj.12813","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T03:36:39Z","timestamp":1505964999000},"page":"1359-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Enhanced wound\u2010healing performance of a phyto\u2010polysaccharide\u2010enriched dressing \u2013 a preclinical small and large animal study"],"prefix":"10.1111","volume":"14","author":[{"given":"Chih\u2010Hsin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tri\u2010Service General Hospital  Taipei Taiwan (R.O.C)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-057X","authenticated-orcid":false,"given":"Shu\u2010Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Yang\u2010Ming University, National Defense Medical Center  Taipei Taiwan (R.O.C)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Sheng","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tri\u2010Service General Hospital  Taipei Taiwan (R.O.C)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jen","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tri\u2010Service General Hospital  Taipei Taiwan (R.O.C)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Adrienne","sequence":"additional","affiliation":[{"name":"Department of Chemistry New York University Abu Dhabi  Abu Dhabi United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyi\u2010Gen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tri\u2010Service General Hospital  Taipei Taiwan (R.O.C)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim\u2010Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tri\u2010Service General Hospital  Taipei Taiwan (R.O.C)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niann\u2010Tzyy","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tri\u2010Service General Hospital  Taipei Taiwan (R.O.C)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juin\u2010Hong","family":"Cherng","sequence":"additional","affiliation":[{"name":"Department and Graduate 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